乳腺浸润性小叶癌组织Ki-67表达与临床病理特征相关性分析
发布时间：2018-11-15 22:31
【摘要】：目的浸润性小叶癌(invasive lobular carcinoma,ILC)组织中Ki-67表达的研究较少,对其预后预测价值尚需进一步文献支持。本研究探讨ILC组织不同临床病理特征下Ki-67表达差异及其与预后的关系。方法收集天津医科大学肿瘤医院2003-01-10-2012-12-15收治的381例乳腺ILC患者的临床病理资料,分析Ki-67与其临床病理特征的相关性。分析不同年龄、月经状态、体质量指数、家族史、肿瘤大小、淋巴结状态、病理学分期、组织学分型、ER状态、PR状态、HER-2状态和p53状态下,Ki-67表达与预后的关系。结果 381例ILC组织中Ki-67低表达76例(19.9%),中表达91例(23.9%),高表达214例(56.2%)。在不同肿物大小(χ~2=12.524,P=0.014)、腋窝淋巴结情况(χ~2=6.114,P=0.047)、临床分期(χ~2=10.434,P=0.034)、ER表达(χ~2=6.339,P=0.041)和组织学类型(χ~2=78.288,P0.001)情况下,Ki-67表达差异有统计学意义。Ki-67表达与肿物大小(r=0.168,P=0.001)、腋窝淋巴结情况(r=0.108,P=0.036)、临床分期(r=0.149,P=0.004)和组织学类型(r=0.532,P0.001)呈正相关。Ki-67表达与ER表达呈负相关,r=-0.112,P=0.029。在肿瘤大小2~5cm、有腋窝淋巴结转移及临床Ⅱ期ILC组织中,Ki-67表达对患者总生存(overall survival,OS)差异有统计学意义,P0.05;而对无病生存(disease-free survival,DFS)差异无统计学意义,P0.05。Cox多因素分析显示,有无淋巴结转移(P=0.000)是ILC总生存的独立预后因素,而肿瘤大小、临床分期和Ki-67表达水平不是影响ILC总生存的独立预后因素,P0.05。结论乳腺ILC组织中Ki-67高表达。就诊时肿物越大、有腋窝淋巴结转移和临床分期越高,Ki-67表达水平越高,而ER表达水平越高,Ki-67表达水平越低,肿物大小2~5cm、有腋窝淋巴结转移及临床Ⅱ期,即中低度恶性ILC组织中Ki-67表达对患者预后有一定的预测价值,但不是独立预后因素,Ki-67对ILC预后预测作用尚需进一步研究。
[Abstract]:Objective to study the expression of Ki-67 in invasive lobular carcinoma (invasive lobular carcinoma,ILC) and its prognostic value need further literature support. The purpose of this study was to investigate the difference of Ki-67 expression in different clinicopathological features of ILC and its relationship with prognosis. Methods the clinicopathological data of 381 patients with breast ILC admitted in Cancer Hospital of Tianjin Medical University from January 10 to December 12, 2003 were collected and the correlation between Ki-67 and its clinicopathological features was analyzed. The relationship between the expression of Ki-67 and prognosis was analyzed under different age, menstrual state, body mass index, family history, tumor size, lymph node status, pathological stage, histological classification, ER status, PR state, HER-2 state and p53 status. Results there were 76 cases (19.9%) with low expression of Ki-67, 91 cases (23.9%) with moderate expression and 214 cases (56.2%) with high expression of Ki-67 in 381 cases of ILC. In different tumor sizes (蠂 ~ 2 ~ 2, 12.524), axillary lymph nodes (蠂 ~ 2 ~ 2, 6.114, P ~ (0.047), clinical stage (蠂 ~ 210.434), P ~ (0.034), ER expression (蠂 ~ (6.339) P ~ (0.041) and histological type (蠂 ~ (78.288), P ~ (0.041). Ki-67 expression and tumor size (rn 0.168 P0. 001), axillary lymph node status (rn 0. 108), clinical stage (rn 0. 149), P0. 001), Ki-67 expression and tumor size (0. 168% P0. 001), axillary lymph node status (0. 108% P0. 036), clinical stage (r = 0. 149, P < 0. The expression of Ki-67 was negatively correlated with the expression of ER. There was a significant difference in total survival (overall survival,OS) between patients with tumor size of 2 ~ 5 cm, axillary lymph node metastasis and clinical stage 鈪，
本文编号：2334587
[Abstract]:Objective to study the expression of Ki-67 in invasive lobular carcinoma (invasive lobular carcinoma,ILC) and its prognostic value need further literature support. The purpose of this study was to investigate the difference of Ki-67 expression in different clinicopathological features of ILC and its relationship with prognosis. Methods the clinicopathological data of 381 patients with breast ILC admitted in Cancer Hospital of Tianjin Medical University from January 10 to December 12, 2003 were collected and the correlation between Ki-67 and its clinicopathological features was analyzed. The relationship between the expression of Ki-67 and prognosis was analyzed under different age, menstrual state, body mass index, family history, tumor size, lymph node status, pathological stage, histological classification, ER status, PR state, HER-2 state and p53 status. Results there were 76 cases (19.9%) with low expression of Ki-67, 91 cases (23.9%) with moderate expression and 214 cases (56.2%) with high expression of Ki-67 in 381 cases of ILC. In different tumor sizes (蠂 ~ 2 ~ 2, 12.524), axillary lymph nodes (蠂 ~ 2 ~ 2, 6.114, P ~ (0.047), clinical stage (蠂 ~ 210.434), P ~ (0.034), ER expression (蠂 ~ (6.339) P ~ (0.041) and histological type (蠂 ~ (78.288), P ~ (0.041). Ki-67 expression and tumor size (rn 0.168 P0. 001), axillary lymph node status (rn 0. 108), clinical stage (rn 0. 149), P0. 001), Ki-67 expression and tumor size (0. 168% P0. 001), axillary lymph node status (0. 108% P0. 036), clinical stage (r = 0. 149, P < 0. The expression of Ki-67 was negatively correlated with the expression of ER. There was a significant difference in total survival (overall survival,OS) between patients with tumor size of 2 ~ 5 cm, axillary lymph node metastasis and clinical stage 鈪，
本文编号：2334587
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