JAK2-STAT3信号通路在肝细胞癌中的研究进展
发布时间：2018-11-22 18:21
【摘要】：近年来发现,JAK2-STAT3信号通路参与肿瘤细胞的生长、增殖、分化、转移、凋亡。在肝细胞癌(HCC)细胞中的JAK蛋白和STAT蛋白过表达,JAK2-STAT3信号通路与HCC发生发展密切相关。笔者就JAK2-STAT3信号通路在HCC的研究进展做一综述。
[Abstract]:In recent years, JAK2-STAT3 signaling pathway has been found to be involved in the growth, proliferation, differentiation, metastasis and apoptosis of tumor cells. Overexpression of JAK protein and STAT protein in hepatocellular carcinoma (HCC) cells, JAK2-STAT3 signaling pathway is closely related to the occurrence and development of HCC. This paper reviews the research progress of JAK2-STAT3 signaling pathway in HCC.
【作者单位】： 中南大学湘雅医院卫生部纳米生物技术重点实验室;
【基金】：国家自然科学基金资助项目(81302075,81272193,81402001)
【分类号】：R735.7
[Abstract]:In recent years, JAK2-STAT3 signaling pathway has been found to be involved in the growth, proliferation, differentiation, metastasis and apoptosis of tumor cells. Overexpression of JAK protein and STAT protein in hepatocellular carcinoma (HCC) cells, JAK2-STAT3 signaling pathway is closely related to the occurrence and development of HCC. This paper reviews the research progress of JAK2-STAT3 signaling pathway in HCC.
【作者单位】： 中南大学湘雅医院卫生部纳米生物技术重点实验室;
【基金】：国家自然科学基金资助项目(81302075,81272193,81402001)
【分类号】：R735.7
【参考文献】
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2 Bo Zhai;Xue-Ying Sun;;Mechanisms of resistance to sorafenib and the corresponding strategies in hepatocellular carcinoma[J];World Journal of Hepatology;2013年07期
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