SORCIN与肿瘤耐药及耐药相关转运体研究进展

发布时间：2018-11-24 10:31

【摘要】：可溶性耐药相关钙结合蛋白(soluble resistance-related calcium-binding protein,SORCIN)是一个22k Da的具有典型"EF-hand"结构的钙结合蛋白,参与细胞内钙稳态调节。SORCIN广泛分布于多种组织,其中在正常的心脏与脑组织中高表达,而在部分肿瘤组织中过表达。近年来,大量的临床数据显示SORCIN与肿瘤耐药性密切相关。基础研究表明SORCIN不仅参与肿瘤细胞多药耐药(multidrug resistance,MDR)的形成,且与肿瘤的恶性程度、不良预后密切相关。此外,部分研究证明SORCIN参与ATP结合盒转运体(ABC transporter)的调节,进而对肿瘤耐药性产生影响。因此,SORCIN有望成为肿瘤耐药诊断及治疗的新靶点。本文对SORCIN及其在肿瘤耐药方面的研究进展进行综述。
[Abstract]:Soluble drug-resistance-associated calcium-binding protein (soluble resistance-related calcium-binding protein,SORCIN) is a 22k Da calcium-binding protein with typical "EF-hand" structure, which participates in intracellular calcium homeostasis regulation. SORCIN is widely distributed in many tissues. It was overexpressed in normal heart and brain tissues and overexpressed in some tumor tissues. In recent years, a large number of clinical data show that SORCIN is closely related to tumor resistance. Basic research shows that SORCIN is not only involved in the formation of multidrug resistance (multidrug resistance,MDR) of tumor cells, but also closely related to the malignancy and poor prognosis of tumor. In addition, some studies have demonstrated that SORCIN is involved in the regulation of ATP binding cassette transporter (ABC transporter) and thus has an effect on tumor resistance. Therefore, SORCIN is expected to be a new target for the diagnosis and treatment of tumor resistance. This article reviews the progress of SORCIN and its application in tumor resistance.
【作者单位】：大连医科大学药学院;
【基金】：国家自然科学基金资助项目(81473280)
【分类号】：R73-3

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