ercc1基因在食管鳞癌中的表达及其临床意义

发布时间：2018-11-26 14:16

【摘要】：目的研究切除修复交叉互补基因1(ercc1)在食管鳞癌中的表达规律与食管鳞癌患者预后的关系及其临床意义。方法采用疫组织化学染色法检测110例食管鳞癌组织及110例远癌组织中ercc1基因的表达水平,分析ercc1基因的表达水平与食管鳞癌临床病理特征的关系以及预后之间的关系。结果ercc1基因在食管鳞癌组织中高表达69例,低表达41例,高表达率为63%,在远癌组织中高表达8例,低表达102例,高表达率为7%;ercc1基因的阳性表达与食管鳞癌患者年龄(χ2=0.006,P=0.940)、性别(χ2=0.034,P=0.854)、肿瘤大小(χ2=1.844,P=0.175)、肿瘤浸润深度(χ2=0.020,P=0.889)、淋巴结转移情况(χ2=0.979,P=0.323)以及酗酒史(χ2=3.816,P=0.051)无相关关系,而与食管鳞状细胞癌患者分化程度(χ2=4.542,P=0.033)和病理分期(χ2=6.203,P=0.013)存在相关性;并且ercc1基因的表达水平与食管鳞癌患者预后有相关关系。结论ercc1基因在食管鳞状细胞癌组织中的高表达率远高于远癌组织,并且erc c1基因的表达与食管鳞状细胞癌患者的细胞分化程度和病理分期存在相关性。且ercc1基因的高表达影响患者预后,ercc1基因高表达患者的生存时间短于ercc1基因低表达患者,因此ercc1基因与食管鳞状细胞癌的发生发展存在相关性,并且可作为食管鳞状细胞癌患者预测预后的指标。
[Abstract]:Objective to study the relationship between the expression of cross complementary gene 1 (ercc1) in esophageal squamous cell carcinoma and the prognosis of esophageal squamous cell carcinoma and its clinical significance. Methods the expression of ercc1 gene in 110 cases of esophageal squamous cell carcinoma and 110 cases of distant carcinoma was detected by immunohistochemical staining. The relationship between the expression of ercc1 gene and the clinicopathological features and prognosis of esophageal squamous cell carcinoma was analyzed. Results there were 69 cases of high expression of ercc1 gene and 41 cases of low expression of ercc1 gene in esophageal squamous cell carcinoma, the high expression rate was 63%. The high expression rate of ercc1 gene in distant carcinoma was 8 cases and low expression in 102 cases, the high expression rate was 7%. The positive expression of ercc1 gene was associated with the age of esophageal squamous cell carcinoma (蠂 2 + 0.006), sex (蠂 2 0. 034), tumor size (蠂 2) 1.84 4 (P 0. 175), depth of tumor invasion (蠂 2 0. 020) and tumor invasion (P 0. 889). There was no correlation between lymph node metastasis (蠂 2 / 0 979) and history of alcoholism (蠂 2 / 3.816 / P = 0.051), but there was no correlation between lymph node metastasis and differentiation degree (蠂 2 / 4.542) and pathological stage (蠂 2 / 6.203) in esophageal squamous cell carcinoma. There was a correlation between P0. 013 and P0. 013. The expression of ercc1 gene was correlated with the prognosis of esophageal squamous cell carcinoma. Conclusion the high expression rate of ercc1 gene in esophageal squamous cell carcinoma is much higher than that in distal carcinoma, and the expression of erc C1 gene is correlated with the degree of cell differentiation and pathological stage of esophageal squamous cell carcinoma. The survival time of patients with high expression of ercc1 gene was shorter than that of patients with low expression of ercc1 gene. Therefore, there was a correlation between ercc1 gene and the occurrence and development of esophageal squamous cell carcinoma. It can be used as a predictor of prognosis in esophageal squamous cell carcinoma.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.1

【参考文献】