CT引导下穿刺活检对Ⅰ期-Ⅱ期非小细胞肺癌远处转移和生存的影响

发布时间：2018-11-26 17:19

【摘要】：背景与目的 CT引导下穿刺活检(computed tomography-guided needle biopsy,CTNB)是诊断肺癌最常用的一种方法,具有诊断准确性高及并发症少的特点。现有的研究表明CTNB可引起肿瘤的针道转移,然而极少有研究关注CTNB对远处转移和远期生存的影响。本研究旨在探讨术前的CTNB对I期-II期非小细胞肺癌(nonsmall cell lung cancer,NSCLC)远处转移和生存的影响。方法研究对象为1,234例I期-II期NSCLC术后患者,其中113例术前行CTNB,1,121例术前未经任何活检。应用倾向性评分匹配方法平衡两组间的临床特征,经配对后纳入后续统计检验共226例。并进一步应用Cox回归分析法和Kaplan-Meier分析法进行生存分析。结果在I期-II期NSCLC患者中,术前的CTNB组无远处转移时间(distant metastasis free survival,DMFS)显著短于无活检组(P=0.032),而两组间总生存无统计学差异(P=0.086)。结论 CT引导下穿刺肺活检可能促进早期肺癌的远处转移,但不影响总生存。
[Abstract]:Background & objective CT guided puncture biopsy (computed tomography-guided needle biopsy,CTNB) is the most commonly used method for the diagnosis of lung cancer with high diagnostic accuracy and less complications. Current studies have shown that CTNB can cause needle metastasis in tumors, but little attention has been paid to the effects of CTNB on distant metastasis and long-term survival. The purpose of this study was to investigate the effect of preoperative CTNB on distant metastasis and survival of stage I-II non-small cell lung cancer (nonsmall cell lung cancer,NSCLC). Methods 1234 patients after stage I-II NSCLC were studied. 113 of them underwent CTNB,1121 without any biopsy before operation. The clinical characteristics of the two groups were balanced by the tendency score matching method. 226 cases were included in the follow-up statistical test after pairing. Furthermore, Cox regression analysis and Kaplan-Meier analysis were used for survival analysis. Results in the patients with stage I to II NSCLC, the time of no distant metastasis (distant metastasis free survival,DMFS) in preoperative CTNB group was significantly shorter than that in non-biopsy group (P0. 032), but there was no significant difference in total survival between the two groups (P0. 086). Conclusion CT guided lung biopsy may promote the distant metastasis of early lung cancer, but it does not affect the overall survival.
【作者单位】：哈尔滨医科大学附属肿瘤医院肿瘤内科;哈尔滨医科大学附属肿瘤医院影像科;
【基金】：国家自然科学基金面上项目(No.81672931) 国家博士后基金项目(No.2016M591552) 黑龙江省科学基金青年基金项目(No.QC2013C091)资助~~
【分类号】：R734.2

【相似文献】