当前位置:主页 > 医学论文 > 肿瘤论文 >

尖吻蝮蛇血凝酶在乳腺癌手术创面的止血作用

发布时间:2018-11-26 21:29
【摘要】:目的评价尖吻蝮蛇血凝酶对乳腺癌手术患者的止血作用及安全性。方法采用前瞻、随机、盲法、对照的研究设计,共纳入符合入排标准并获得知情同意的乳腺癌患者60例,随机分为研究组和对照组,每组各30例;研究组于术前20 min静脉注射尖吻蝮蛇血凝酶2 U,术后4和24 h再次注射2 U,对照组对应时间给予生理盐水;观察记录术中出血量、术后1~3 d创面引流量及创面总引流量;同时观察凝血功能变化和安全性,以及临床结局指标。结果研究组术中出血量(95.0±48.3)g较对照组(144.8±105.4)g显著减少(t=-2.07,P=0.044);研究组术后创面总引流量(166.7±71.2)g显著少于对照组(251.4±166.3)g(t=-2.29,P=0.029);凝血功能指标两组比较差异无统计学意义。两组患者未出现血栓等并发症;住院时间两组比较差异无统计学意义[(15.92±2.32)d比(15.00±3.53)d,t=-1.057,P=0.297]。未出现研究药物相关的不良事件。结论尖吻蝮蛇血凝酶对乳腺癌手术创面的止血作用较好,未增加血栓形成的风险,有较好的安全性。
[Abstract]:Objective to evaluate the hemostatic effect and safety of Agkistrodon acutus hemagglutinin on breast cancer patients. Methods A total of 60 breast cancer patients who met the admission criteria and obtained informed consent were enrolled in a prospective, randomized, blind and controlled study design. They were randomly divided into study group and control group with 30 cases in each group. In the study group, blood coagulase 2U was injected intravenously 20 min before operation, and 2 U was injected again at 4 and 24 hours after operation. The control group was given normal saline at the corresponding time, and the amount of intraoperative bleeding was recorded, and the wound drainage volume and total wound drainage flow were observed 1 and 3 days after operation. At the same time, the changes of coagulation function and safety, as well as the clinical outcome index were observed. Results the intraoperative bleeding volume in the study group (95.0 卤48.3) g was significantly lower than that in the control group (144.8 卤105.4) g (t = 2.07 卤0.044). The total wound drainage volume (166.7 卤71.2g) in the study group was significantly lower than that in the control group (251.4 卤166.3) g (/ t), and there was no significant difference in coagulation function between the two groups. There were no complications such as thrombus in the two groups, and there was no significant difference in hospitalization time between the two groups [(15.92 卤2.32) d vs (15.00 卤3.53) d ~ (-1. 57) P ~ (-1) 0.297]. There were no adverse events related to the study of drugs. Conclusion the hemostatic effect of Agkistrodon acutus hemagglutinin on the wound of breast cancer surgery is better, but the risk of thrombosis is not increased.
【作者单位】: 北京医院普外科;
【分类号】:R737.9

【相似文献】

相关期刊论文 前2条

1 翁剑武;邱陆芬;;尖吻蝮蛇血凝酶用于老年腹部手术患者切口止血的疗效[J];中国老年学杂志;2013年20期

2 ;[J];;年期



本文编号:2359671

资料下载
论文发表

本文链接:https://www.wllwen.com/yixuelunwen/zlx/2359671.html


Copyright(c)文论论文网All Rights Reserved | 网站地图 |

版权申明:资料由用户d1ede***提供,本站仅收录摘要或目录,作者需要删除请E-mail邮箱bigeng88@qq.com