口腔鳞癌人群相对生存率的分析

发布时间：2018-12-06 16:43

【摘要】：目的:初步分析国内外口腔鳞癌的相对生存率现况和变化,为口腔鳞癌诊治工作的研究提供基础数据和初步的效果评价。方法:计算机检索相关期刊论文(CJFD)、中国知网全文数据库、万方全文数据库、PUBMED数据库等,系统的搜集对1970年1月至2016年12月公开发表的、以人群为基础的口腔鳞癌的生存资料进行分析,严格制定纳入标准:发病的解剖范围包括颊粘膜、上下牙龈、磨牙后区、口底、硬腭和舌前2/3,病理分型为鳞状细胞癌,数据均来自国家或地区的以人群为基础的生存资料,以资料中的相对生存率(relative survival rate,RSR)为研究指标,对不同国家或地区间口腔鳞癌的相对生存率及其变化进行比较。结果:初步检索共搜集到相关文献118篇。经过筛选,将来源于全人群、提供了口腔鳞癌的观察生存(observed survival rate,OSR)和相对生存率(relative survival rate,RSR)的文献保留,对生存信息重复不全或非全人群的资料进行删除,最终符合纳入要求的文献共有49篇,其中中文文献14篇,英文文献35篇。通过比较我们发现从1970年至1999年,不同国家和地区的口腔鳞癌的相对生存率均呈现稳步提高状态,2000年至今部分国家或地区的口腔鳞癌相对生存率提高缓慢或呈相对持平状态。我国总体口腔鳞癌5年相对生存率较西方发达国家仍处于相对落后状态。中国上海地区的口腔鳞癌5年相对生存率随着时间的发展呈稳步提高的趋势,到21世纪初期已达到世界先进水平。北京、天津、台湾等地区的口腔鳞癌相对生存率高于江苏启东、福建及湖南省的生存率水平。国外资料表明,欧洲和美国的口腔鳞癌相对生存率较高,而南美洲、非洲的生存率较低。总体上大部分国家或地区男性的口腔鳞癌相对生存率低于女性;口腔鳞癌的相对生存率与年龄的增长呈负相关。结论:随着时间的发展口腔鳞癌的生存率呈不断提高,但整体仍处于较低的水平;我国口腔鳞癌生存率水平有所提高,部分地区接近或达到西方发达国家水平,部分地区仍有一定差距。
[Abstract]:Objective: to analyze the relative survival rate of oral squamous cell carcinoma (OSCC) at home and abroad, and to provide basic data and preliminary effect evaluation for the diagnosis and treatment of OSCC. Methods: the full text database of (CJFD), Wanfang full text database and PUBMED database were searched by computer. The data were collected and published from January 1970 to December 2016. The survival data of oral squamous cell carcinoma (OSCC) based on population were analyzed, and the inclusion criteria were strictly formulated: the anatomical range of the disease included buccal mucosa, upper and lower gingiva, posterior molar region, floor of mouth, hard palate and front of tongue, and pathological classification was squamous cell carcinoma. The relative survival rate of oral squamous cell carcinoma (OSCC) in different countries or regions was compared with the relative survival rate (relative survival rate,RSR). Results: a total of 118 literatures were preliminarily searched. After screening, the literature of oral squamous cell carcinoma (observed survival rate,OSR) and relative survival rate (relative survival rate,RSR) were preserved, and the data of incomplete or incomplete survival information were deleted. There were 49 articles, 14 in Chinese and 35 in English. From 1970 to 1999, we found that the relative survival rate of oral squamous cell carcinoma (OSCC) in different countries and regions increased steadily, and the relative survival rate of OSCC in some countries or regions has been increasing slowly or in a relatively flat state since 2000. The overall 5-year relative survival rate of oral squamous cell carcinoma in China is still relatively backward than that in western developed countries. The 5-year relative survival rate of oral squamous cell carcinoma (OSCC) in Shanghai, China, has steadily increased with the development of time, and has reached the advanced level of the world by the beginning of 21 ~ (st) century. The relative survival rate of oral squamous cell carcinoma in Beijing, Tianjin and Taiwan was higher than that in Qidong, Fujian and Hunan provinces. Foreign data show that the relative survival rate of oral squamous cell carcinoma is higher in Europe and the United States, but lower in South America and Africa. In general, the relative survival rate of male oral squamous cell carcinoma was lower than that of female, and the relative survival rate of oral squamous cell carcinoma was negatively correlated with the increase of age. Conclusion: the survival rate of oral squamous cell carcinoma (OSCC) increases with the development of time, but the overall survival rate is still at a low level. The survival rate of oral squamous cell carcinoma (OSCC) in China has been improved, some areas are close to or up to the level of western developed countries, and some areas still have a certain gap.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R739.8

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