乳腺浸润性导管癌中CD44、TRIM24、TAGLN-2、ER、PR的表达及其临床意义

发布时间：2018-12-09 13:34

【摘要】：目的探讨PI3K-AKT信号通路分子CD44、TRIM24、TAGLN-2、ER、PR在乳腺浸润性导管癌中的表达及其临床意义。方法应用免疫组化EnVision两步法检测73例乳腺浸润性导管癌组织中CD44、TRIM24、TAGLN-2、ER、PR的表达,分析其与临床病理特征的关系及表达的相关性。结果 CD44、TRIM24、TAGLN-2、ER、PR的表达与患者年龄、肿瘤大小、组织学分级及淋巴结转移无明显相关性。CD44与TAGLN-2表达呈正相关(r=0.311,P=0.007);TRIM24与TAGLN-2表达呈正相关(r=0.421,P=0.000);CD44与ER表达呈负相关(r=-0.285,P=0.015);ER与PR表达呈正相关(r=0.598,P=0.000)。CD44阳性组患者术后5年累积生存率低于CD44阴性组(P=0.002);ER阳性组患者术后5年累积生存率高于ER阴性组(P=0.026)。结论在乳腺癌中CD44、TRIM24可能通过激活PI3K-AKT信号通路上调TAGLN-2表达,CD44可能通过激活PI3KAKT信号通路下调ER表达。CD44、ER有望成为预测乳腺浸润性导管癌患者预后的辅助因子,联合检测CD44、ER、PR的表达有助于乳腺浸润性导管癌治疗策略的选择及优化。
[Abstract]:Objective to investigate the expression and clinical significance of PI3K-AKT signaling molecule CD44,TRIM24,TAGLN-2,ER,PR in breast invasive ductal carcinoma. Methods the expression of CD44,TRIM24,TAGLN-2,ER,PR in 73 cases of breast invasive ductal carcinoma was detected by immunohistochemical EnVision two-step method. The relationship between CD44,TRIM24,TAGLN-2,ER,PR expression and clinicopathological features was analyzed. Results there was no significant correlation between the expression of CD44,TRIM24,TAGLN-2,ER,PR and age, tumor size, histological grade and lymph node metastasis. There was a positive correlation between the expression of CD44 and TAGLN-2 (r = 0.311P ~ (0.007). There was a positive correlation between TRIM24 and TAGLN-2 (r = 0.421), a negative correlation between CD44 and ER (r = 0.285), and a negative correlation between CD44 and ER (r = 0.285). There was a positive correlation between the expression of ER and PR (r = 0.598). The 5-year cumulative survival rate in the CD44 positive group was lower than that in the CD44 negative group (P0. 002); ER positive group was higher than that in the ER negative group (P0. 026). Conclusion in breast cancer, CD44,TRIM24 may up-regulate the expression of TAGLN-2 by activating PI3K-AKT signaling pathway, and CD44 may down-regulate ER expression by activating PI3KAKT signaling pathway. CD44,ER may be an auxiliary factor in predicting the prognosis of breast invasive ductal carcinoma. Combined detection of CD44,ER,PR expression is helpful to the selection and optimization of treatment strategies for invasive ductal carcinoma of breast.
【作者单位】：四川大学华西基础医学与法医学院法医病理教研室;徐州医学院附属医院病理科;
【分类号】：R737.9

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