艾迪注射液改善乳腺癌患者情绪及生活质量的临床观察
发布时间：2018-12-20 11:58
【摘要】：目的:观察艾迪注射液是否可以改善乳腺癌患者抑郁、焦虑情绪。观察艾迪注射液是否可以改善乳腺癌患者生活质量。材料与方法:选取辽宁省肿瘤医院内一科2016年3月至2016年8月住院的乳腺癌患者,共50例。采用前瞻性随机对照临床研究方法,将符合条件的患者随机分成试验组(n=24)和对照组(n=26)。试验组,在常规西医治疗的同时,静滴艾迪注射液(10 m L/支),100 m L+加入0.9%氯化钠注射液或5%葡萄糖注射液400-450ml静脉点滴,每日1次,连续治疗7日,停药14日,21日为1周期,连续应用2周期。对照组:空白对照,只接受常规西医治疗。记录第1周期开始和第2周期结束,两组患者焦虑自评量表(SAS)、抑郁自评量表(SDS)及生活质量调查表(QLQ-C30)评分,观察评分变化情况,同时观察艾迪注射液的不良反应。结果:1.试验组和对照组,两组患者在性别、年龄、体力状况评分、临床分期方面具有较好的均衡性,(均有P0.05)。2.试验组和对照组两组肿瘤缓解率(ORR)比较,检验结果:P0.05没有统计学意义。3.试验组治疗前后焦虑量表评分比较,检验结果:P0.05有统计学差异,治疗后优于治疗前;对照组治疗前后焦虑量表评分比较,检验结果:P0.05无统计学差异;试验组和对照组治疗后组间焦虑量表评分比较,检验结果:P0.05有统计学差异,试验组优于对照组。4.试验组治疗前后抑郁量表评分比较,检验结果:P0.05有统计学差异,治疗后优于治疗前;对照组治疗前后抑郁量表评分比较,检验结果:P0.05无统计学差异;试验组和对照组治疗后组间抑郁量表评分比较,检验结果:P0.05有统计学差异,试验组优于对照组。5.试验组治疗前后生活质量调查表各项评分比较,检验结果:疲倦症状领域和总体健康状况领域评分P0.05有统计学差异,治疗后优于治疗前,其余各项检验结果:P0.05均无统计学差异;对照组治疗前后生活质量调查表各项评分比较,疲倦、腹泻症状领域评分P0.05有统计学差异,治疗前优于治疗后,其余各项检验结果:P0.05均无统计学差异。结论:1.艾迪注射液可改善乳腺癌患者的抑郁情绪。2.艾迪注射液可改善乳腺癌患者的焦虑情绪。3.艾迪注射液可改善乳腺癌患者的生活质量。
[Abstract]:Objective: to observe whether Aidi injection can improve depression and anxiety in breast cancer patients. To observe whether Aidi injection can improve the quality of life of breast cancer patients. Materials and methods: 50 breast cancer patients from March 2016 to August 2016 in Liaoning Cancer Hospital were selected. Prospective randomized controlled clinical study was used to randomly divide the eligible patients into two groups: the trial group (n = 24) and the control group (n = 26). In the experimental group, Aidi injection (10 mL / branch) was injected intravenously with 0.9% sodium chloride injection or 5% glucose injection 400-450ml intravenously at the same time of routine western medicine treatment for 7 consecutive days. Drug withdrawal for 14 days, 21 days for 1 cycle, continuous application of 2 cycles. Control group: blank control group, only accepted routine western medicine treatment. At the beginning of the first cycle and the end of the second cycle, the scores of self-rating anxiety scale (SAS), self-rating depression scale (SDS) and quality of life (QLQ-C30) were recorded, and the changes of the scores were observed. At the same time, the adverse reactions of Aidi injection were observed. Results: 1. Test group and control group, the two groups of patients in gender, age, physical strength scores, clinical stages have a better balance, (P0.05). 2. Test group and control group tumor remission rate (ORR) comparison, test results: P0.05 no statistical significance. The test group before and after treatment anxiety scale score comparison, test results: P0.05 has statistical difference, after treatment is better than before treatment; the control group before and after treatment anxiety scale score comparison, test results: P0.05 no statistical difference; Test group and control group after treatment between the anxiety scale score comparison, test results: P0.05 has statistical difference, the test group is better than the control group. 4. Test group before and after treatment depression scale score comparison, test results: P0.05 has statistical difference, after treatment is better than before treatment; the control group before and after treatment depression scale score comparison, test results: P0.05 no statistical difference; Test group and control group after treatment between the depression scale score comparison, test results: P0.05, the test group is better than the control group. 5. The scores of QOL questionnaire were compared before and after treatment in the trial group. The results showed that there were significant differences in the scores of fatigue symptom area and general health status (P0.05), which were better than those before and after treatment. The other test results: P0.05, there was no statistical difference; Control group before and after treatment quality of life questionnaire scores, fatigue, diarrhea symptoms P05 scores were statistically significant, before treatment than after treatment, the rest of the test results: P0.05 no statistical difference. Conclusion: 1. Aidi injection can improve depression in breast cancer patients. 2. 2. Eddie injection can improve anxiety in breast cancer patients. Eddie injection can improve the quality of life of breast cancer patients.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.9
本文编号：2387966
[Abstract]:Objective: to observe whether Aidi injection can improve depression and anxiety in breast cancer patients. To observe whether Aidi injection can improve the quality of life of breast cancer patients. Materials and methods: 50 breast cancer patients from March 2016 to August 2016 in Liaoning Cancer Hospital were selected. Prospective randomized controlled clinical study was used to randomly divide the eligible patients into two groups: the trial group (n = 24) and the control group (n = 26). In the experimental group, Aidi injection (10 mL / branch) was injected intravenously with 0.9% sodium chloride injection or 5% glucose injection 400-450ml intravenously at the same time of routine western medicine treatment for 7 consecutive days. Drug withdrawal for 14 days, 21 days for 1 cycle, continuous application of 2 cycles. Control group: blank control group, only accepted routine western medicine treatment. At the beginning of the first cycle and the end of the second cycle, the scores of self-rating anxiety scale (SAS), self-rating depression scale (SDS) and quality of life (QLQ-C30) were recorded, and the changes of the scores were observed. At the same time, the adverse reactions of Aidi injection were observed. Results: 1. Test group and control group, the two groups of patients in gender, age, physical strength scores, clinical stages have a better balance, (P0.05). 2. Test group and control group tumor remission rate (ORR) comparison, test results: P0.05 no statistical significance. The test group before and after treatment anxiety scale score comparison, test results: P0.05 has statistical difference, after treatment is better than before treatment; the control group before and after treatment anxiety scale score comparison, test results: P0.05 no statistical difference; Test group and control group after treatment between the anxiety scale score comparison, test results: P0.05 has statistical difference, the test group is better than the control group. 4. Test group before and after treatment depression scale score comparison, test results: P0.05 has statistical difference, after treatment is better than before treatment; the control group before and after treatment depression scale score comparison, test results: P0.05 no statistical difference; Test group and control group after treatment between the depression scale score comparison, test results: P0.05, the test group is better than the control group. 5. The scores of QOL questionnaire were compared before and after treatment in the trial group. The results showed that there were significant differences in the scores of fatigue symptom area and general health status (P0.05), which were better than those before and after treatment. The other test results: P0.05, there was no statistical difference; Control group before and after treatment quality of life questionnaire scores, fatigue, diarrhea symptoms P05 scores were statistically significant, before treatment than after treatment, the rest of the test results: P0.05 no statistical difference. Conclusion: 1. Aidi injection can improve depression in breast cancer patients. 2. 2. Eddie injection can improve anxiety in breast cancer patients. Eddie injection can improve the quality of life of breast cancer patients.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.9
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