人体血液天然结构生育酚水平与肺癌发生相关性分析
发布时间：2018-12-23 19:14
【摘要】：目的:探讨中国东北地区汉族人群,人体血液中天然结构生育酚水平与肺癌发生相关性。方法:回顾性分析2010年1月1日至2015年12月31日期间,于吉林大学第一医院就诊肺癌患者150例及于健康门诊同期随访体检人群150例。应用超高效液相色谱法测定上述血液标本中α-生育酚及γ-生育酚水平。采用Logistic回归模型分析人体血液中α-生育酚及γ-生育酚水平与肺癌发生的相关因素。结果:Logistic回归:血液中α-生育酚及γ-生育酚水平在肺癌组中明显降低,且具有显著性统计学差异。(α-生育酚血液水平:OR比值95%可信区间[5.249-803.17]P值0.001;γ-生育酚血液水平:OR比值95%可信区间[1.539-7.582]P值0.001)。且不受年龄,性别,采血季节,肺癌家族史,吸烟,饮酒,ECOG评分等多种因素影响。(α-生育酚血液水平:OR比值95%可信区间[1537.5-64.832]P值0.001;丫-生育酚血液水平:OR比值95%可信区间[8.253-2.987]P值0.001)。结论:中国东北地区汉族人群中,在肺癌人群中人体血液内α-生育酚及γ-生育酚水平下降为肺癌发生独立危险因素。具备显著统计学意义。
[Abstract]:Objective: to investigate the correlation between natural structure tocopherol and lung cancer in the Han population in Northeast China. Methods: from January 1, 2010 to December 31, 2015, 150 patients with lung cancer were treated in the first Hospital of Jilin University and 150 patients were followed up at the same time. The levels of 伪-tocopherol and 纬-tocopherol in blood samples were determined by ultra-high performance liquid chromatography. Logistic regression model was used to analyze the correlation between the levels of 伪 -tocopherol and 纬 -tocopherol in human blood and the occurrence of lung cancer. Results: Logistic regression showed that the levels of 伪 -tocopherol and 纬 -tocopherol in blood were significantly decreased in lung cancer group. (伪 -tocopherol blood level: 95% confidence interval of OR ratio [5.249-803.17] P 0.001; Blood level of 纬 -tocopherol: 95% confidence interval of OR ratio [1.539-7.582] P value 0.001). It was not affected by age, sex, blood collection season, family history of lung cancer, smoking, drinking, ECOG score, etc. (伪 -tocopherol blood level: 95% confidence interval of OR ratio [1537.5-64.832] P 0.001; Ya-tocopherol blood level: OR ratio 95% confidence interval [8.253-2.987] P value 0.001). Conclusion: the levels of 伪 -tocopherol and 纬 -tocopherol in human blood are independent risk factors of lung cancer in the Han population of Northeast China. It has significant statistical significance.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2
[Abstract]:Objective: to investigate the correlation between natural structure tocopherol and lung cancer in the Han population in Northeast China. Methods: from January 1, 2010 to December 31, 2015, 150 patients with lung cancer were treated in the first Hospital of Jilin University and 150 patients were followed up at the same time. The levels of 伪-tocopherol and 纬-tocopherol in blood samples were determined by ultra-high performance liquid chromatography. Logistic regression model was used to analyze the correlation between the levels of 伪 -tocopherol and 纬 -tocopherol in human blood and the occurrence of lung cancer. Results: Logistic regression showed that the levels of 伪 -tocopherol and 纬 -tocopherol in blood were significantly decreased in lung cancer group. (伪 -tocopherol blood level: 95% confidence interval of OR ratio [5.249-803.17] P 0.001; Blood level of 纬 -tocopherol: 95% confidence interval of OR ratio [1.539-7.582] P value 0.001). It was not affected by age, sex, blood collection season, family history of lung cancer, smoking, drinking, ECOG score, etc. (伪 -tocopherol blood level: 95% confidence interval of OR ratio [1537.5-64.832] P 0.001; Ya-tocopherol blood level: OR ratio 95% confidence interval [8.253-2.987] P value 0.001). Conclusion: the levels of 伪 -tocopherol and 纬 -tocopherol in human blood are independent risk factors of lung cancer in the Han population of Northeast China. It has significant statistical significance.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2
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