谷胱甘肽S转移酶P1和4-HNE在前列腺癌中的表达及其临床意义

发布时间：2018-12-28 13:08

【摘要】：目的:探讨谷胱甘肽S转移酶P1(GSTP1)和四羟基壬烯(4-HNE)在前列腺癌组织中的表达及其临床意义。方法:采用免疫组化方法检测40例前列腺癌组织及42例BPH组织中GSTP1和4-HNE的表达,分析GSTP1和4-HNE的表达与Gleason分级之间的关系。结果:GSTP1在BPH组织中为高表达(92.9%),40例前列腺癌组织中GSTP1表达率在高、中、低分化癌中分别为58.3%、20.0%、16.7%,呈下降趋势,两组GSTP1表达差异有统计学意义(P0.01)。4-HNE在前列腺增生组织中阳性表达率较低,仅为5.0%。40例前列腺癌组织中4-HNE高表达,在高、中、低分化癌中分别为91.6%、100.0%、100.0%,呈明显上升趋势,两组4-HNE表达差异有统计学意义(P0.01)。前列腺癌组织中GSTP1和4-HNE阳性表达呈负相关(r=-2.73,P0.01)。结论:GSTP1表达缺失和4-HNE的高表达,可能在前列腺癌的进展中起重要作用。
[Abstract]:Aim: to investigate the expression and clinical significance of glutathione S transferase P1 (GSTP1) and tetrahydroxynonene (4-HNE) in prostate cancer. Methods: immunohistochemical method was used to detect the expression of GSTP1 and 4-HNE in 40 cases of prostate cancer and 42 cases of BPH. The relationship between the expression of GSTP1 and 4-HNE and Gleason grade was analyzed. Results: the expression of GSTP1 was high in BPH tissues (92.9%), and the expression rate of GSTP1 was high in 40 cases of prostate cancer, 58.3% and 20.0% in poorly differentiated carcinomas, respectively, showing a downward trend. The expression of GSTP1 was significantly different between the two groups (P0.01). The positive expression rate of 4-HNE in benign prostatic hyperplasia was lower, only 5.0.40 cases of prostate cancer had high expression of 4-HNE. The expression of 4-HNE in the poorly differentiated carcinoma was 91.6% and 100.0%, respectively, which showed a significant upward trend. There was significant difference in the expression of 4-HNE between the two groups (P0.01). The positive expression of GSTP1 and 4-HNE in prostate cancer tissues was negatively correlated (r-2. 73 P 0. 01). Conclusion: loss of GSTP1 expression and overexpression of 4-HNE may play an important role in the progression of prostate cancer.
【作者单位】：上海中医药大学附属第七人民医院泌尿外科;
【基金】：上海市浦东新区卫生和计划生育委员会重点专科基金资助项目(PWZz 2013-16) 上海市卫生和计划生育委员会科研基金资助项目(201440545)
【分类号】：R737.25

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