吉林大学中日联谊医院胸外科患者肺癌临床特征及诊治方法2005年与2015年的对比研究

发布时间：2018-12-31 13:24

【摘要】：背景与目的:原发性支气管肺癌(简称肺癌)在目前恶性肿瘤中发病率和死亡率最高且较为常见,本文目的在于回顾性研究2005年与2015年吉林大学中日联谊医院胸外科患者肺癌临床特征及诊治方法,为肺癌患者的早期诊断及早期治疗提供依据。方法:收集2005年与2015年吉林大学中日联谊医院胸外科住院患者中首诊诊断为肺癌的病例,基于两组患者的不同就诊模式、平均就诊时间、合并其它疾病、肺癌合并其它类型癌的双原发癌、家族恶性肿瘤病史、肺癌发生位置,以及初诊主要治疗手段等对收集的临床资料进行了对比和分析。结果:收集了有明确组织学病理依据的原发性支气管肺癌患者病例共计1610例,其中2005年410例,2015年1200例。在2005年至2015年这10年中因体检发现问题而就诊的原发性支气管肺癌患者所占比例提高(6.3%vs18.2%,p0.001),患者平均就诊时间缩短(p0.001),有一级亲属的恶性肿瘤史的肺癌患者数增多(5.6%vs15.8%,p0.001);NSCLC(非小细胞肺癌)患者IV期和Ia期所占比例显著上升(Ia期:1.5%vs5.4%,p0.001;IV期:31.5%vs38.6%,p0.001),IIIa期肿瘤所占比例明显降低(24.5%vs12.6%,p=0.002);患NSCLS(非小细胞肺癌)的患者在治疗上初诊诊行化疗治疗的比例升高(33.4%vs53.6%,p=0.008),IIIa期初诊选择行手术治疗的患者所占比例显著提高(47.6%vs72.5%,p=0.002)。结论:2005至2015这十年间原发性支气管肺癌患者的一部分临床特征已经发生了显著的变化,以这些变化为基础制定出更合理的方案对肺癌的预防、诊断和治疗及降低肺癌发病率,延长生存期有一定意义。
[Abstract]:Background & objective: primary bronchial lung cancer (lung cancer) has the highest morbidity and mortality among malignant tumors. The purpose of this paper is to study retrospectively the clinical features, diagnosis and treatment of lung cancer in the thoracic surgery department of Sino-Japanese Friendship Hospital of Jilin University in 2005 and 2015, so as to provide the basis for early diagnosis and treatment of lung cancer patients. Methods: the first diagnosed lung cancer cases were collected from thoracic surgery inpatients of Sino-Japanese Friendship Hospital of Jilin University in 2005 and 2015. The clinical data of double primary carcinoma with other types of lung cancer, family malignant tumor history, location of lung cancer, and primary treatment were compared and analyzed. Results: a total of 1610 cases of primary bronchial lung cancer with clear histopathological basis were collected, including 410 cases in 2005 and 1200 cases in 2015. Between 2005 and 2015, the proportion of patients with primary bronchial lung cancer who were diagnosed by medical examinations increased (6.3 vs 18.2 / p0.001), and the average duration of visits was shortened (p0.001), The number of lung cancer patients with a history of malignant tumor in first-degree relatives increased (5.6 vs 15.8cm, p0.001); The proportion of IV and Ia in patients with NSCLC (non-small cell lung cancer) increased significantly (Ia: 1.5 vs 5.4 and P 0.001); IV stage: the proportion of tumor in 31.5% vs 38.6% was significantly lower than that in), IIIa stage (24.5vs12.6%, p0.002). The proportion of patients with NSCLS (non-small cell lung cancer) receiving chemotherapy at first visit was significantly increased (33.4% vs 53.6%, p 0.008), IIIa), and the proportion of patients undergoing surgical treatment was significantly increased (47.6 vs 72.5%). P0. 002). Conclusion: significant changes have taken place in some clinical features of patients with primary bronchial lung cancer during the past ten years from 2005 to 2015. Based on these changes, a more reasonable program has been developed to prevent, diagnose and treat lung cancer and to reduce the incidence of lung cancer. Prolonging the survival time has certain significance.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2

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