P53表达对胃癌预后影响的Meta分析

发布时间：2019-01-06 20:04

【摘要】：目的:P53过表达参与了胃癌的形成和进展,众多的研究已探索了p53表达与胃癌预后的关系,但仍未达成共识。此Meta分析旨在定量评价p53表达在胃癌患者预后的价值。方法:本研究用计算机系统检索了Pubmed和Embase数据库(建库-2014年2月25),收集p53表达与胃癌预后相关的英文文献。采用合并的危险比(Hazard ratio,HR)和比值比(Odds ratio,OR)值及其95%可信区间(Confidence interval,CI)作为效应量。此外,我们根据人种、HR值提取方法、生存分析及纳入研究质量评分进行了Meta回归分析和亚组分析。结果:本研究共纳入了34个研究,包括6599名患者,进行了最终分析。结果表明:p53过表达与胃癌患者的总生存期(Overall survival,OS)(HR=1.56,95%CI:1.23 1.98)及疾病特异生存期(Disease specific survival,DSS)(HR=1.52,95%CI:1.35 1.73)存在显著的统计学相关性。p53过表达也与性别(OR=1.26,95%CI:1.09 1.45),Lauren分型(OR=1.68,95%CI:1.23 2.29),肿瘤浸润深度(OR=0.68,95%CI:0.56 0.83),淋巴结转移(OR=1.56,95%CI:1.23 1.97),TNM分期(OR=0.57,95%CI:0.47 0.69),血管侵犯(OR=1.51,95%CI:1.18 1.92)及淋巴管侵犯(OR=1.38,95%CI:1.11 1.72)存在显著的相关性,而与Bormann分型(OR=1.24,95%CI:0.91 1.70),分化程度(OR=1.08,95%CI:0.82 1.44)及远处转移(OR=1.37,95%CI:0.92 2.03)无显著统计学相关性。结论:本研究表明p53过表达可以作为预测胃癌患者更差预后的分子标志物。
[Abstract]:Objective: p53 overexpression is involved in the formation and progression of gastric cancer. Many studies have explored the relationship between p53 expression and prognosis of gastric cancer, but there is still no consensus. The purpose of this Meta analysis was to quantitatively evaluate the prognostic value of p53 expression in patients with gastric cancer. Methods: in this study, Pubmed and Embase databases were searched by computer system. English literature on p53 expression and prognosis of gastric cancer was collected. The combined risk ratio (Hazard ratio,HR), ratio (Odds ratio,OR) and 95% confidence interval (Confidence interval,CI) were used as the effect. In addition, we performed Meta regression analysis and subgroup analysis according to race, HR value extraction method, survival analysis and inclusion study quality score. Results: a total of 34 studies, including 6599 patients, were analyzed. The results showed that p53 overexpression was associated with total survival (Overall survival,OS) (HR=1.56,95%CI:1.23 1.98) and disease-specific survival (Disease specific survival,) in patients with gastric cancer. P53 overexpression was also associated with sex (OR=1.26,95%CI:1.09 1.45), Lauren typing (OR=1.68,95%CI:1.23 2.29). Tumor invasion depth (OR=0.68,95%CI:0.56) was 0.83, lymph node metastasis (OR=1.56,95%CI:1.23) was 1.97), TNM stage (OR=0.57,95%CI:0.47 = 0.69). Vascular invasion (OR=1.51,95%CI:1.18 1.92) and lymphatic vessel invasion (OR=1.38,95%CI:1.11 1.72) were significantly correlated with Bormann typing (OR=1.24,95%CI:0.91 1.70). There was no significant correlation between the degree of differentiation (OR=1.08,95%CI:0.82 1.44) and distant metastasis (OR=1.37,95%CI:0.92 2.03). Conclusion: this study suggests that p53 overexpression may be a molecular marker for predicting worse prognosis in patients with gastric cancer.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R735.2

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