超声双重造影对评判及预测胃癌伴肝转移新辅助化疗的价值

发布时间：2019-01-07 19:16

【摘要】：目的探讨超声双重造影对预测及评判胃癌伴肝转移新辅助化疗患者疗效的应用价值。方法胃癌伴肝转移新辅助化疗患者82例,根据病情分为有效组(62例)与进展组(20例),对比两组化疗前后超声双重造影参数,统计术后病理组织微血管密度(MVD),分析造影参数与MVD的相关性。结果治疗后3个周期峰值强度(PI)显著低于治疗前,开始增强时间(RT)、到达峰值时间(TTP)显著高于治疗前(P0.05);有效组PI显著低于进展组,RT、TTP均高于对照组(P0.05);MVD(68.23±15.21)条/200倍视野显著低于进展组(75.55±10.61)条(P=0.017),PI与MVD呈正相关,RT、TTP与MVD呈负相关。结论超声双重造影参数、PI能有效预测与评判胃癌伴肝转移新辅助化疗效果,且敏感性较高。
[Abstract]:Objective to evaluate the value of dual contrast-enhanced ultrasonography in predicting and evaluating the efficacy of neoadjuvant chemotherapy in patients with gastric cancer with liver metastasis. Methods 82 patients with neoadjuvant chemotherapy for gastric cancer with liver metastasis were divided into effective group (62 cases) and progressive group (20 cases) according to their condition. The parameters of contrast-enhanced ultrasound before and after chemotherapy were compared, and the microvessel density (MVD),) of pathological tissue after operation was counted. The correlation between imaging parameters and MVD was analyzed. Results the peak intensity of (PI) in three cycles after treatment was significantly lower than that before treatment, and the peak time of (RT), at the beginning of enhancement was significantly higher than that before treatment (P0.05). The PI of the effective group was significantly lower than that of the progressive group, and the RT,TTP of the effective group was higher than that of the control group (P0.05). MVD (68.23 卤15.21) / 200fold visual field was significantly lower than that of progressive group (75.55 卤10.61) (P < 0.017), PI was positively correlated with MVD, RT,TTP was negatively correlated with MVD). Conclusion PI can predict and evaluate the neoadjuvant chemotherapeutic effect of gastric cancer with liver metastasis, and its sensitivity is high.
【作者单位】：海南省农垦总医院超声医学科;
【基金】：海南省自然科学基金(20106221)
【分类号】：R445.1;R735.2

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