对羟基苯丙氨酸（酪氨酸）尿液检测在乳腺肿瘤诊疗中的应用

发布时间：2019-01-10 18:38

【摘要】：研究背景与目的:近些年来,乳腺癌的发病率逐步提高,已跃居女性恶性肿瘤之首[1]。对广大女性的生命健康造成极大威胁。早发现、早诊断及早治疗是提高乳腺癌患者治愈率的关键[2]。目前乳腺肿瘤的检查方法主要包括:乳房查体、超声、乳腺X线摄影、核磁共振成像、肿瘤标志物以及活组织病理检查等。但以上各种检查手段均需到医院进行检查,或具有繁琐、高成本、有创等缺点,不适合作为乳腺癌高危人群的大规模筛查。近年来,尿液标本在肿瘤筛查中的应用发展迅速,并且具有操作简单、无创、性价比高等优点。目前针对尿液中对羟基苯丙氨酸在恶性肿瘤早期筛查的研究较少。本研究将采用对羟基苯丙氨酸尿液检测试剂,针对乳腺肿瘤的检测进行研究,并探讨其在乳腺癌高危人群筛查中的临床应用价值。研究方法:分别检测2016年3月至2016年6月,于吉林大学第二医院体检健康女性50人。以及在此期间吉林大学第二医院乳腺外科收治的患者,挑选乳腺良性肿物患者及乳腺癌患者各50人。检测结果通过SPSS21.0软件包进行数据的统计分析和处理。结果:健康女性50人中,检测结果阳性1人,阴性49人,阳性率2%(1/50);50例乳腺良性肿物的患者,检测结果阳性2人,阴性48人,阳性率4%(2/50);50例乳腺癌的患者,术前检测阳性结果44人,阴性结果6人,阳性率88%(44/50),对这50名患者进行了手术治疗后的追踪检测,手术治疗后阳性率为6%(3/50)。结论:1.对羟基苯丙氨酸(酪氨酸)尿液检测不能作为乳腺良性肿物检测方法。2.对羟基苯丙氨酸(酪氨酸)尿液检测可以作为乳腺癌检测的一种方法,且同时具有取材方便、无创、操作简单、所需时间短的特点,可以作为乳腺癌自检的一种手段。
[Abstract]:Background & objective: in recent years, the incidence of breast cancer has gradually increased, and has leapt to the top of the female malignant tumor [1]. It is a great threat to the lives and health of women. Early detection, early diagnosis and early treatment is the key to improve the cure rate of breast cancer patients [2]. At present, the examination methods of breast tumor include breast examination, ultrasound, mammography, magnetic resonance imaging, tumor markers and histopathological examination. However, all the methods mentioned above need to be checked in hospitals, or have the disadvantages of tedious, high cost, invasive and so on, so they are not suitable for large-scale screening of high risk groups of breast cancer. In recent years, the application of urine samples in tumor screening has developed rapidly, and has the advantages of simple operation, non-invasive, cost-effective and so on. There are few studies on early screening of p-hydroxyphenylalanine in urine for malignant tumors. The purpose of this study was to study the detection of breast tumors with p-hydroxyphenylalanine urine detection reagent and to explore its clinical value in screening high risk population of breast cancer. Methods: from March 2016 to June 2016, 50 healthy women were examined in the second Hospital of Jilin University. During this period, 50 patients with benign breast masses and 50 patients with breast cancer were selected from the Department of Breast surgery, the second Hospital of Jilin University. The results were analyzed and processed by SPSS21.0 software package. Results: among the 50 healthy women, the positive rate was 2% (1 / 50) and the positive rate was 4% (2 / 50) in the 50 cases of benign breast masses. The positive rate was 88% (44 / 50) in 50 patients with breast cancer. The positive rate was 6% (3 / 50) after operation. Conclusion: 1. Urine detection of p-hydroxyphenylalanine (tyrosine) cannot be used as a method for detection of benign breast masses. 2. Urine detection of p-hydroxyphenylalanine (tyrosine) can be used as a method for detection of breast cancer.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.9

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