MTA1表达与中国肺癌患者预后关系的meta分析
发布时间：2019-01-18 08:27
【摘要】：背景与目的已有的研究表明:在多种恶性肿瘤中发现转移相关蛋白1(metastasis associated protein1,MTA1)发挥着促进肿瘤侵袭与转移的作用,且与肿瘤患者预后不佳有关。目前MTA1在肺癌中的预后作用仍有争议,故我们采用meta分析的方法评估其在肺癌患者中的预后价值。方法通过计算机检索PubMed、Embase、万方数据库、中国生物医学文献数据库、中国知网等数据库,收集纳入研究MTA1表达与肺癌预后关系的文献及相关数据,采用Stata 12.0软件进行数据分析,合并值为风险比(hazard ratio,HR)。结果总共纳入8项研究共712例中国肺癌患者,对这些研究进行异质性检验,发现存在异质性(I~2=59.0%,P=0.017),故采用随机效应模型进行数据合并得HR=2.07(95%CI:1.42-3.02,P0.001)。同时分层分析显示在非小细胞肺癌(non-small cell lung cancer,NSCLC)中各研究无明显异质性(I~2=47.0%,P=0.093),采用固定效应模型合并得HR=1.66(95%CI:1.27-2.18,P0.001)。结论 MTA1高表达可能是中国NSCLC患者预后不良的一个指标,在肺癌及小细胞肺癌中的预后价值尚缺乏证据。
[Abstract]:Background & AIM previous studies have shown that metastasis associated protein 1 (metastasis associated protein1,MTA1) plays a role in promoting tumor invasion and metastasis in various malignant tumors and is related to poor prognosis of tumor patients. At present, the prognostic role of MTA1 in lung cancer is still controversial, so we use the method of meta analysis to evaluate its prognostic value in patients with lung cancer. Methods PubMed,Embase, Wanfang database, Chinese biomedical literature database and China knowledge network database were searched by computer to collect the literature and related data about the relationship between the expression of MTA1 and the prognosis of lung cancer. Stata 12.0 software was used to analyze the data, and the combined value was risk ratio (hazard ratio,HR). Results A total of 712 patients with lung cancer in China were enrolled in 8 studies. The heterogeneity of these studies was tested and heterogeneity was found. Therefore, the random effect model is used to combine the data to obtain HR=2.07 (95 CI: 1.42-3.02 P0.001). At the same time, stratification analysis showed that there was no significant heterogeneity in all studies of non-small cell lung cancer (non-small cell lung cancer,NSCLC). The fixed effect model was used to combine HR=1.66 (95 CI: 1.27-2.18). P0.001) Conclusion the high expression of MTA1 may be an indicator of poor prognosis in patients with NSCLC in China, and the prognostic value in patients with lung cancer and small cell lung cancer is still lack of evidence.
【作者单位】： 南京医科大学附属南京医院呼吸科;
【基金】：江苏省临床医学科技专项(No.BE2015611)资助~~
【分类号】：R734.2
本文编号：2410504
[Abstract]:Background & AIM previous studies have shown that metastasis associated protein 1 (metastasis associated protein1,MTA1) plays a role in promoting tumor invasion and metastasis in various malignant tumors and is related to poor prognosis of tumor patients. At present, the prognostic role of MTA1 in lung cancer is still controversial, so we use the method of meta analysis to evaluate its prognostic value in patients with lung cancer. Methods PubMed,Embase, Wanfang database, Chinese biomedical literature database and China knowledge network database were searched by computer to collect the literature and related data about the relationship between the expression of MTA1 and the prognosis of lung cancer. Stata 12.0 software was used to analyze the data, and the combined value was risk ratio (hazard ratio,HR). Results A total of 712 patients with lung cancer in China were enrolled in 8 studies. The heterogeneity of these studies was tested and heterogeneity was found. Therefore, the random effect model is used to combine the data to obtain HR=2.07 (95 CI: 1.42-3.02 P0.001). At the same time, stratification analysis showed that there was no significant heterogeneity in all studies of non-small cell lung cancer (non-small cell lung cancer,NSCLC). The fixed effect model was used to combine HR=1.66 (95 CI: 1.27-2.18). P0.001) Conclusion the high expression of MTA1 may be an indicator of poor prognosis in patients with NSCLC in China, and the prognostic value in patients with lung cancer and small cell lung cancer is still lack of evidence.
【作者单位】： 南京医科大学附属南京医院呼吸科;
【基金】：江苏省临床医学科技专项(No.BE2015611)资助~~
【分类号】：R734.2
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