弓形虫非复制型尿嘧啶营养缺陷型疫苗株对肿瘤的免疫治疗作用

发布时间：2019-01-28 06:54

【摘要】：刚地弓形虫(Toxoplasma gondii)是一种单细胞寄生原虫,入侵机体后可诱导机体产生抗弓形虫免疫应答,这种免疫应答与抗肿瘤免疫应答有相似之处。近年的研究发现,弓形虫非复制型尿嘧啶营养缺陷型疫苗株(nonreplicating avirulent uracil auxotroph vaccine strain,cps)能有效地抑制多种实体瘤的进展。本文就弓形虫cps株对小鼠卵巢癌、胰腺癌和黑色素瘤的免疫治疗进展进行综述,以期为个体化癌症免疫治疗提供有价值的参考。
[Abstract]:Toxoplasma gondii (Toxoplasma gondii) is a single-cell parasitic protozoa, which can induce the immune response against Toxoplasma gondii after invading the organism, and this immune response is similar to the anti-tumor immune response. In recent years, it has been found that Toxoplasma gondii (nonreplicating avirulent uracil auxotroph vaccine strain,cps) can effectively inhibit the progress of various solid tumors. The progress of immunotherapy of mouse ovarian cancer, pancreatic cancer and melanoma with Toxoplasma cps strain was reviewed in this paper, in order to provide valuable reference for individualized immunotherapy of cancer.
【作者单位】：中山大学中山医学院寄生虫学教研室热带病防治研究教育部重点实验室广东省媒介生物防控工程技术研究中心;
【基金】：国家自然科学基金(No.81271854,81471973) 广东省科技计划项目(No.2014A020212108)~~
【分类号】：R730.51

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