巨噬细胞集落刺激因子在宫颈癌及宫颈上皮内瘤变患者血清中的表达及意义
发布时间：2019-03-05 16:09
【摘要】：目的检测巨噬细胞集落刺激因子(M-CSF)在宫颈癌及宫颈上皮内瘤变(CIN)患者血清中的表达水平,探讨其在宫颈癌发展过程中的作用及早期诊断中的价值。方法选择2014年6月至2016年6月间确诊的宫颈癌患者49例、CIN患者60例、健康体检者40例为研究对象,采取血清标本,分别运用ELISA及MEIA法检测M-CSF、SCC-Ag表达水平。结果 M-CSF和SCCAg在宫颈癌患者血清中表达水平显著高于健康对照组及CIN组(均P0.01)。M-CSF在CIN组的表达显著高于正常对照组(P0.05),且高级别CIN组显著高于低级别CIN组(P0.05),但SCC-Ag在CIN组及正常对照组的表达差异无统计学意义(P0.05)。联合检测SCC-A和M-CSF显著提高宫颈癌检出率。M-CSF在宫颈癌及高级别CIN患者术后均降低至正常水平,手术前后相比差异有统计学意义(P0.05),SCCAg则只有在宫颈癌组手术前、后表达差异有统计学意义(P0.05)。结论 M-CSF可能成为宫颈癌和CIN诊断中有用的血清学指标,可望用于预测CIN和宫颈癌的转归。
[Abstract]:Aim to detect the expression of macrophage colony stimulating factor (M-CSF) in serum of patients with cervical cancer and cervical intraepithelial neoplasia (CIN), and to explore its role in the development of cervical cancer and its value in early diagnosis. Methods from June 2014 to June 2016, 49 patients with cervical cancer, 60 patients with CIN and 40 healthy subjects were selected as the subjects. Serum samples were taken to detect the expression of MC-CSF and SCC-Ag by ELISA and MEIA, respectively. Results the expression level of M-CSF and SCCAg in serum of cervical cancer patients was significantly higher than that of healthy control group and CIN group (P0.01), and the expression of M-CSF in CIN group was significantly higher than that of normal control group (P0.05). The expression of SCC-Ag in the high-grade CIN group was significantly higher than that in the low-grade CIN group (P0.05), but there was no significant difference in the expression of SCC-Ag between the CIN group and the normal control group (P0.05). Combined detection of SCC-A and M-CSF significantly increased the detection rate of cervical cancer. M-CSF decreased to normal level in cervical cancer and high-grade CIN patients after operation, and the difference was statistically significant before and after operation (P0.05). There was significant difference in SCCAg expression only before and after operation in cervical cancer group (P0.05). Conclusion M-CSF may be a useful serological marker in the diagnosis of cervical cancer and CIN, and can be used to predict the prognosis of CIN and cervical cancer.
【作者单位】： 南方医科大学附属佛山市妇幼保健院妇科;
【基金】：广东省医学科研基金(编号:A2014703)
【分类号】：R737.33
本文编号：2435081
[Abstract]:Aim to detect the expression of macrophage colony stimulating factor (M-CSF) in serum of patients with cervical cancer and cervical intraepithelial neoplasia (CIN), and to explore its role in the development of cervical cancer and its value in early diagnosis. Methods from June 2014 to June 2016, 49 patients with cervical cancer, 60 patients with CIN and 40 healthy subjects were selected as the subjects. Serum samples were taken to detect the expression of MC-CSF and SCC-Ag by ELISA and MEIA, respectively. Results the expression level of M-CSF and SCCAg in serum of cervical cancer patients was significantly higher than that of healthy control group and CIN group (P0.01), and the expression of M-CSF in CIN group was significantly higher than that of normal control group (P0.05). The expression of SCC-Ag in the high-grade CIN group was significantly higher than that in the low-grade CIN group (P0.05), but there was no significant difference in the expression of SCC-Ag between the CIN group and the normal control group (P0.05). Combined detection of SCC-A and M-CSF significantly increased the detection rate of cervical cancer. M-CSF decreased to normal level in cervical cancer and high-grade CIN patients after operation, and the difference was statistically significant before and after operation (P0.05). There was significant difference in SCCAg expression only before and after operation in cervical cancer group (P0.05). Conclusion M-CSF may be a useful serological marker in the diagnosis of cervical cancer and CIN, and can be used to predict the prognosis of CIN and cervical cancer.
【作者单位】： 南方医科大学附属佛山市妇幼保健院妇科;
【基金】：广东省医学科研基金(编号:A2014703)
【分类号】：R737.33
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