乳腺癌组织中FOXM1和PLK1的表达及意义

发布时间：2019-03-07 16:38

【摘要】：目的探讨叉头框转录因子M1(FOXM1)及Polo样激酶1(PLK1)在乳腺癌组织中的表达及临床意义。方法采用免疫组织化学法检测FOXM1及PLK1蛋白在803例乳腺浸润性导管癌和乳腺癌旁组织中的表达情况及其与乳腺癌组织临床病理特征间的关系。结果 FOXM1及PLK1在乳腺浸润性导管癌组织中的阳性表达率分别为59.78%(480/803)和27.90%(224/803),显著高于其在乳腺癌旁组织中的表达(29.89%,0),差异具有统计学意义(χ~2=145.011,χ~2=260.307,P=0.000)。FOXM1及PLK1蛋白的表达与乳腺癌的组织学分级、淋巴结转移及临床分期相关,而与肿瘤大小无关,且二者表达具有正相关关系(r=0.414,P0.01)。结论 FOXM1及PLK-1可能协同参与了乳腺癌的发生、发展,并可能成为乳腺癌预后评估的重要指标。
[Abstract]:Objective to investigate the expression and clinical significance of forkhead frame transcription factor M1 (FOXM1) and Polo-like kinase 1 (PLK1) in breast cancer. Methods Immunohistochemistry was used to detect the expression of FOXM1 and PLK1 protein in 803 cases of breast invasive ductal carcinoma and adjacent breast cancer and the relationship between the expression and clinicopathological features of breast cancer. Results the positive expression rate of FOXM1 and PLK1 in breast invasive ductal carcinoma was 59.78% (480 / 803) and 27.90% (224 / 803) respectively, which was significantly higher than that in adjacent breast cancer tissues (29.89%, 0). The difference was statistically significant (蠂 ~ 2 / 145.011, 蠂 ~ 2 / 260.307, P = 0.000). The expression of FoxM1 and PLK1 protein was correlated with histological grade, lymph node metastasis and clinical stage of breast cancer, but not with tumor size. There was a positive correlation between the expression of them (r = 0.414, P0.01). Conclusion FOXM1 and PLK-1 may be involved in the occurrence and development of breast cancer, and may be an important index for prognosis evaluation of breast cancer.
【作者单位】：保定市第一中心医院病理科;保定市第一中心医院皮肤科;保定市第一中医院病理科;保定市第三中心医院普通外科;保定市第一中心医院重症医学科;涿州市妇产医院妇产科;
【分类号】：R737.9

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