中药外敷脐贴辅助治疗含顺铂方案化疗引起胃肠道反应的临床研究

发布时间：2019-03-16 13:03

【摘要】：目的:通过对50例应用紫杉醇+顺铂方案化疗的肿瘤患者进行中药外敷脐贴治疗,观察中药外敷脐贴辅助盐酸帕洛诺司琼注射液、地塞米松磷酸钠注射液治疗含顺铂方案化疗引起的胃肠道反应的疗效,评价其对胃肠道不良反应的缓解和控制情况,从而为中药外敷脐贴辅助治疗含顺铂方案化疗引起的胃肠道反应的临床研究,提供进一步的支持和参考。方法:按照纳入标准和排除标准,收集了2016年1月至2016年12月于山东中医药大学附属医院肿瘤科住院,并予紫杉醇+顺铂方案化疗的患者50例。将入选病例按照随机数表法分为观察组和对照组,每组各25例。对照组仅予盐酸帕洛诺司琼注射液和地塞米松磷酸钠注射液;观察组在对照组的基础上,予中药外敷脐贴治疗。观察治疗后两组患者胃肠道不良反应的分级情况,综合评价中药外敷脐贴辅助盐酸帕洛诺司琼注射液和地塞米松磷酸钠注射液,治疗含顺铂方案化疗引起的胃肠道反应的疗效及安全性。结果:观察组25例患者中,呕吐发生率为28%,腹胀发生率为36%,便秘发生率为36%;对照组25例患者中,呕吐发生率为68%,腹胀发生率为92%,便秘发生率为80%。两组结果的差异具有显著性的意义(PO.05),观察组的治疗效果优于对照组。两组患者治疗后,在呕吐、腹胀、便秘等中医症状分级量化的比较上也有显著性的意义(PO.05),观察组的治疗效果优于对照组。结论:中药外敷脐贴辅助盐酸帕洛诺司琼注射液和地塞米松磷酸钠注射液,对含顺铂方案化疗引起胃肠道反应的治疗效果,从呕吐、腹胀、便秘方面比较,要明显优于单一使用盐酸帕洛诺司琼注射液和地塞米松磷酸钠注射液,且方便易行、安全性高、效优价廉。
[Abstract]:Objective: to observe 50 cases of tumor patients treated with paclitaxel cisplatin chemotherapy with external application of traditional Chinese medicine umbilical cord paste and paronosetron hydrochloride injection. The efficacy of dexamethasone sodium phosphate injection in the treatment of gastrointestinal reactions induced by cisplatin-containing chemotherapy was evaluated, and the relief and control of adverse reactions to gastrointestinal tract were evaluated. In order to provide further support and reference for the clinical study of external application of traditional Chinese medicine umbilical cord paste in the treatment of gastrointestinal reaction induced by chemotherapy with cisplatin-containing regimen. Methods: according to the inclusion criteria and exclusion criteria, 50 patients who were hospitalized in the Department of Oncology, affiliated Hospital of Shandong University of traditional Chinese Medicine from January 2016 to December 2016, were treated with paclitaxel cisplatin regimen. The patients were divided into observation group (n = 25) and control group (n = 25) according to random table method. The control group was treated only with parosetron hydrochloride injection and dexamethasone sodium phosphate injection, and the observation group was treated with external application of traditional Chinese medicine umbilical cord paste on the basis of the control group. To observe the grading of gastrointestinal adverse reactions in the two groups after treatment, and to evaluate the external application of traditional Chinese medicine in the treatment of umbilical cord paste assisted with parosetron hydrochloride injection and dexamethasone sodium phosphate injection. Efficacy and safety of chemotherapy-induced gastrointestinal reaction in patients with cisplatin-containing chemotherapy. Results: the incidence of vomiting, abdominal distension and constipation was 28%, 36% and 36% in the observation group and 68%, 92% and 80% in the control group, respectively. The difference between the two groups was significant (PO.05), and the therapeutic effect of the observation group was better than that of the control group. After treatment, there was significant difference (PO.05) between the two groups in the quantification of TCM symptoms, such as vomiting, abdominal distension and constipation, and the therapeutic effect of the observation group was better than that of the control group. Conclusion: the external application of traditional Chinese medicine navel paste in combination with paloxetron hydrochloride injection and dexamethasone sodium phosphate injection, in the treatment of gastrointestinal reaction induced by chemotherapy with cisplatin regimen, was compared in terms of vomiting, abdominal distension and constipation. It is superior to parosetron hydrochloride injection and dexamethasone sodium phosphate injection alone, and is convenient, safe, effective and cheap.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R730.53

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