盐酸羟考酮缓释片联合加巴喷丁胶囊治疗癌性疼痛的临床观察

发布时间：2019-03-28 18:09

【摘要】：目的观察盐酸羟考酮缓释片联合加巴喷丁胶囊治疗癌性疼痛的临床疗效及安全性。方法 55例中、重度癌痛的恶性肿瘤患者随机分为两组,盐酸羟考酮缓释片联合加巴喷丁胶囊组(A组)28例,单纯盐酸羟考酮缓释片组(B组)27例。比较两组患者治疗前后疼痛缓解程度、盐酸羟考酮缓释片的日均用量、生活质量评分和不良反应。结果两组患者治疗后的疼痛缓解程度数字评分(NRS)均较治疗前降低(P0.05),但A组疼痛缓解大于B组,差异有统计学意义(P0.05)。A组患者的羟考酮日均用量少于B组,差异有统计学意义(P0.05)。两组患者生活质量评分均较治疗前有所改善(P0.05);与B组比较,A组患者改善更明显,差异有统计学意义(P0.05)。两组主要不良反应为便秘、恶心、呕吐、头晕,两组差异无统计学意义(P0.05)。结论盐酸羟考酮缓释片联合加巴喷丁胶囊能有效治疗中、重度癌痛,减少羟考酮的用量,不良反应少,并能提高患者生活质量。
[Abstract]:Objective to observe the clinical efficacy and safety of oxycodone hydrochloride sustained-release tablets combined with bapentin capsules in the treatment of cancer pain. Methods 55 patients with moderate to severe cancer pain were randomly divided into two groups: group A (n = 28) treated with oxycodone hydrochloride sustained-release tablets and group B (n = 27) treated with oxycodone hydrochloride sustained-release tablets (group A) and group B (n = 27). The pain relief degree, daily average dosage of oxycodone hydrochloride sustained-release tablets, quality of life score and adverse reactions were compared between the two groups before and after treatment. Results the scores of (NRS) after treatment in both groups were lower than those before treatment (P0.05), but the pain relief in group A was greater than that in group B, but the pain relief in group A was higher than that in group B. The average daily dose of oxycodone in). A group was lower than that in B group (P0.05). The quality of life scores of the two groups were improved (P0.05), and the improvement of group A was more obvious than that of group B, the difference was statistically significant (P0.05). The main adverse reactions of the two groups were constipation, nausea, vomiting and dizziness. There was no significant difference between the two groups (P0.05). Conclusion Oxycodone hydrochloride sustained-release tablets combined with bapentin capsule can effectively treat moderate and severe cancer pain, reduce the dosage of oxycodone, and improve the quality of life of patients.
【作者单位】：湖南中医药大学中西医结合学院;湘潭市第二人民医院肿瘤科;
【分类号】：R730.5

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