61例淋巴瘤患者自体外周血造血干细胞动员方案临床分析

发布时间：2019-03-31 08:22

【摘要】：目的:比较化疗+G-CSF与化疗+G-CSF+GM-CSF方案对淋巴瘤患者外周血造血干细胞动员采集及造血重建的效果差异。方法:回顾性分析2008年5月至2016年10月天津医科大学肿瘤医院血液科收治的61例行自体外周血造血干细胞移植(autologous peripheral blood stem cell transplantation,APBSCT)的淋巴瘤患者,分别采用化疗+G-CSF或化疗+G-CSF+GM-CSF方案动员外周血造血干细胞的临床资料。分析动员采集效果及移植后造血重建、发热、抗生素应用等情况。结果:动员期间所有患者白细胞计数均降至1.0×109/L以下,血小板计数降至40×109/L以下。化疗+G-CSF组患者采集CD34+细胞数的成功率明显低于化疗+G-CSF+GM-CSF组(52.5%vs.90.5%,P=0.003)。所有患者移植后均顺利完成造血重建,无移植相关死亡。化疗+G-CSF组和化疗+G-CSF+GM-CSF组中性粒细胞、血小板恢复时间及回输后发热、抗生素使用情况差异均无统计学意义(P0.05)。结论:化疗+G-CSF+GM-CSF组动员CD34+细胞产率虽然明显高于化疗+G-CSF组,然而移植成功率、中性粒细胞恢复时间、血小板恢复时间及不良反应均无显著性差异,本研究认为化疗+G-CSF+GM-CSF动员方案并未优于化疗+G-CSF动员方案。
[Abstract]:Aim: to compare the effects of chemotherapy G-CSF and chemotherapy G-CSF GM-CSF regimen on peripheral blood stem cell mobilization and hematopoietic reconstruction in lymphoma patients. Methods: 61 cases of lymphoma treated with autologous peripheral blood stem cell transplantation (autologous peripheral blood stem cell transplantation,APBSCT) in the Department of Hematology, Cancer Hospital of Tianjin Medical University from May 2008 to October 2016 were retrospectively analyzed. The clinical data of peripheral blood stem cells were mobilized by chemotherapy G-CSF or G-CSF GM-CSF regimen respectively. The effect of mobilization and collection, hematopoiesis reconstruction, fever and antibiotic application after transplantation were analyzed. Results: the leukocyte count and platelet count decreased to less than 1.0 脳 109 渭 L and 40 脳 109 渭 L in all patients during mobilization. The success rate of collecting CD34 cells in G-CSF group was significantly lower than that in G-CSF GM-CSF group (52.5% vs. 90.5%, P < 0.003). All patients completed hematopoiesis reconstruction successfully after transplantation, and no transplantation-related death was found. There was no significant difference in neutrophil, platelet recovery time, fever and antibiotic use between G-CSF group and G-CSF GM-CSF group (P0.05). Conclusion: although the rate of mobilized CD34 cells in G-CSF GM-CSF group was significantly higher than that in G-CSF group, there was no significant difference in success rate of transplantation, recovery time of neutrophil, platelet recovery time and adverse reaction. This study suggests that chemotherapy G-CSF GM-CSF mobilization regimen is not superior to chemotherapy G-CSF mobilization regimen.
【作者单位】：天津医科大学肿瘤医院血液科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心;
【基金】：国家自然科学基金项目(编号:81600163、81570201)资助~~
【分类号】：R733.1

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