柴苓杉贝汤联合RCHOP方案治疗气郁痰结型NHL的临床疗效观察

发布时间：2019-04-09 18:53

【摘要】：目的：评价柴苓杉贝汤联合RCHOP方案治疗气郁痰结型NHL(非霍奇金淋巴瘤)的临床疗效及安全性。方法：用随机数字法把符合入组标准的72例患者分为中药加化疗组(A组)和化疗组(B组),各36例。两组均接受了2周期的RCHOP方案的化疗,其中A组于RCHOP方案化疗开始同时口服中药柴苓杉贝汤,150m1/次,日两次(早晚)。观察治疗后骨髓抑制情况；外周血象(WBC, NEUT, PLT, Hb)变化情况；中医临床症状及生存质量的变化情况；肝肾功、心电异常发生情况。结果：1疗效评价：骨髓抑制发生率A组为68.57%,B组为94.29%,A组较B组低,差异有统计学意义(P0.05)。A组与B组骨髓抑制分度比较,差异有统计学意义(P0.05)。与B组相比,A组治疗后血象降低幅度小,差异有统计学意义(P0.05)。中医症状改善有效率A组为65.71%,B组为8.57%,A组高于B组,差异有统计学意义(P0.05)。A组与B组中医症状改善分度比较,差异有统计学意义(P0.05)。与B组相比,A组治疗后中医症状总积分和单个中医症状积分下降幅度均较大,差异有统计学意义(P0.05)。与B组相比,A组治疗后KPS评分提高幅度较大,差异有统计学意义(P0.05)。2肝肾功和心电图异常发生评价：肾功正常；肝功异常情况对比(P0.05),差异无统计学意义,心电异常情况对比(P0.05),差异无统计学意义。结论：1.柴苓杉贝汤可以降低化疗骨髓抑制发生率和改善骨髓抑制程度。2.柴苓杉贝汤可以改善血象降低情况。3.柴苓杉贝汤可以改善中医临床症状和改善患者生存质量。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of Chailing Shanbei decoction combined with RCHOP regimen in the treatment of NHL (non-Hodgkin's lymphoma) with qi depression and phlegm. Methods: 72 patients were randomly divided into two groups: group A (n = 36) and group B (n = 36), who were treated with Chinese medicine plus chemotherapy (group A) and chemotherapy group (group B, n = 36). Two cycles of RCHOP chemotherapy were given to both groups, in which group A took Chailing Shanbei decoction orally at the beginning of RCHOP regimen, 150m1/ twice a day (sooner or later). The changes of myelosuppression, peripheral blood (WBC, NEUT, PLT, Hb), clinical symptoms and quality of life of traditional Chinese medicine, liver and kidney function and abnormal ECG were observed after treatment. Results: 1 Evaluation of curative effect: the incidence of myelosuppression was 68.57% in group A and 94.29% in group B, which was significantly lower in group A than in group B (P0.05:). A group and B group). The difference was statistically significant (P0.05). Compared with group B, the hemogram of group A decreased slightly after treatment, the difference was statistically significant (P0.05). The effective rate of TCM symptom improvement in group A was 65.71%, group B was 8.57%, group A was higher than group B, the difference was statistically significant (P0.05). A group and B group, the difference was statistically significant (P0.05). Compared with group B, the total score of TCM symptom and the score of single symptom decreased significantly in group A after treatment, the difference was statistically significant (P0.05). Compared with group B, the scores of KPS in group A increased significantly after treatment (P0.05). (2) Evaluation of abnormal liver and kidney function and ECG: normal renal function; Liver function abnormality situation contrast (P0.05), the difference is not statistically significant, the ECG abnormal situation contrast (P0.05), the difference is not statistically significant. Conclusion: 1. Chailing Shanbei decoction can reduce the incidence of chemotherapy myelosuppression and improve the degree of myelosuppression. 2. Chailing shanbei decoction can improve the decrease of hemogram. 3. Chailing Shanbei decoction can improve the clinical symptoms of traditional Chinese medicine and improve the quality of life of patients.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R733.1

【相似文献】

相关期刊论文 前10条

1 蔡青山;柴胡青陈汤加减治疗气郁咳嗽48例[J];河北中医;2005年08期

2 马汴梁;;浅论气郁[J];山东中医杂志;1986年02期

3 王建刚;;浅论气郁[J];陕西中医函授;1989年04期

4 陈霞波;苏琼;;血虚气郁体质从肝论[J];中国民族民间医药;2010年24期

5 刘美之;倪诚;;中医气郁体质与方药干预研究述评[J];山西中医学院学报;2012年03期

6 王鹏;;气郁体质的研究进展[J];中国保健营养;2013年06期

7 ;妊娠气郁案[J];浙江中医杂志;2001年12期

8 冯娜;贺娟;王琦;;气郁体质相关差异基因研究[J];中国中西医结合杂志;2011年01期

9 ;气郁体质怎样养生[J];科技视界;2011年13期

10 刘存光;;气郁体质的养生:演艺明星多气郁(上)[J];卓越理财;2013年10期

相关会议论文 前2条

1 王芙蓉;周凤珍;宋蕾;;气郁体质之食药养生[A];中华中医药学会第八届中医体质研讨会暨中医健康状态认知与体质辨识研究论坛论文集[C];2010年

2 苏荣立;范宇;;浅谈治气郁失眠症之体会[A];中华中医药学会中医、中西医结合治疗常见病研讨会论文集[C];2007年

相关重要报纸文章 前3条

1 河北省沧州中西医结合医院治未病中心 侯献兵;气郁体质调养有招[N];中国中医药报;2013年

2 衣晓峰 张锐;调查显示：哈尔滨八成市民体质“气郁”兼“痰湿”[N];中国医药报;2014年

3 南京中医药大学周仲瑛名医工作室 郭立中　朱W，

本文编号：2455439