氨甲环酸对肝癌患者肝切除手术出血量及术后凝血功能的影响

发布时间：2019-05-05 08:22

【摘要】：目的观察氨甲环酸对肝癌患者肝切除手术出血量及术后凝血功能的影响。方法将70例进行肝切除手术的肝癌患者随机分为试验组与对照组,每组35例。对照组给予0.9%Na Cl注射液10 mg·kg~(-1),静脉注射;试验组给予氨甲环酸注射液10 mg·kg~(-1),静脉注射,2组均为手术前0.5 h使用。对2组患者的手术出血量及术后凝血功能进行比较。结果试验组和对照组的手术时间分别为(157.98±22.36),(154.98±23.65)min,肝门阻断时间分别为(30.14±5.64),(28.79±5.79)min,差异均无统计学意义(均P0.05)。试验组和对照组的术中输血量分别为(879.65±59.36),(1054.91±61.32)m L,手术出血量分别为(768.97±45.65),(869.64±46.69)m L,红细胞悬液输注量分别为(1.36±0.59),(2.01±0.65)U,差异均有统计学意义(均P0.05)。术后24h,试验组和对照组的活化部分凝血活酶时间(APTT)分别为(41.56±5.46),(43.19±5.69)s,凝血酶原时间(PT)分别为(13.48±3.16),(14.59±2.49)s,血小板(PLT)分别为(167.89±35.87)×109/L,(162.35±41.59)×109/L,差异均无统计学意义(均P0.05);试验组和对照组的纤维蛋白原(FIB)分别为(3.48±0.56),(3.01±0.59)g·L~(-1),差异有统计学意义(P0.05)。2组在治疗过程中均未发生明显的药物不良反应。结论肝癌患者进行肝切除手术前,给予氨甲环酸注射,可减少患者的手术出血量,改善患者术后的凝血功能。
[Abstract]:Objective to observe the effect of carbacycloic acid on blood loss and coagulation function after hepatectomy in patients with hepatocellular carcinoma (HCC). Methods 70 patients with liver cancer underwent hepatectomy were randomly divided into test group and control group with 35 cases in each group. The control group was given 0.9%Na Cl injection 10 mg kg~ (- 1) intravenously, and the test group was given carbamate injection 10 mg kg~ (- 1) intravenously. The two groups were given 0.5 hours before operation. The bleeding volume and coagulation function were compared between the two groups. Results the operation time of the experimental group and the control group were (157.98 卤22.36), (154.98 卤23.65) min, and (30.14 卤5.64), (28.79 卤5.79) min, respectively (P 0.05). The intraoperative blood transfusion was (879.65 卤59.36), (1054.91 卤61.32) m L,) in the experimental group and (768.97 卤45.65), (869.64 卤46.69) m L,) in the control group. The infusion volume of red blood cell suspension was (1.36 卤0.59), (2.01 卤0.65) U, the difference was statistically significant (P 0.05). At 24 h after operation, the activated partial thromboplastin time (APTT) and prothrombin time (PT) were (41.56 卤5.46), (43.19 卤5.69) s and (13.48 卤3.16), (14.59 卤2.49) s, respectively. Platelet (PLT) were (167.89 卤35.87) 脳 109 mL and (162.35 卤41.59) 脳 109 mL, respectively, and there was no significant difference (P 0.05). The fibrinogen (FIB) of test group and control group were (3.48 卤0.56), (3.01 卤0.59) g 路L ~ (- 1), (3.48 卤0.56) g 路L ~ (- 1), respectively. The difference was statistically significant (P0.05). There were no significant adverse drug reactions in the two groups. Conclusion Carbamate injection before hepatectomy can reduce the amount of bleeding and improve the coagulation function of the patients after hepatectomy. [WT5 "HZ] conclusion [WT5" BZ] [WT5 "BZ]
【作者单位】：安徽卫生健康职业学院附属医院普外科;池州市人民医院肝胆外科;池州市人民医院急诊外科;池州市第二人民医院普外科;
【基金】：安徽省高等学校省级质量工程基金资助项目(2013sxzx051) 安徽省教育厅高等职业教育创新发展行动计划项目骨干专业基金资助项目(182-XM01) 安徽省高校人文社科研究重点基金资助项目(SK2016A0339)
【分类号】：R735.7

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