222例晚期结直肠癌疗效评价和预后多因素分析

发布时间：2019-05-09 14:14

【摘要】：目的：分析影响晚期结直肠癌患者的疗效及预后的因素。方法：通过病例资料回顾和随访,回顾性分析2004年1月至2014年12月收治的222例晚期结直肠癌患者资料,对患者各项临床因素使用Log-rank法(单因素分析)及Cox模型(多变量分析),统计这些因素与预后之间的相关性。结果：(1)年龄、是否手术、是否化疗、CEA、CA199与患者总生存期存在相关性,其中年龄、是否手术、是否化疗存在极显著的相关性；(2)年龄、是否化疗、CA199、 CEA、手术方式等5个因素是影响晚期结直肠癌预后的主要因素,其中CEA及手术方式显著影响；(3)手术患者的生存时间明显长于未手术的患者,其中原发灶切除+转移灶切除患者的总生存时间原发灶切除患者的总生存时间姑息手术患者的总生存时间,手术加上射频的患者的近期疗效好于单单手术的患者能够获得更好的近期疗效。结论：年龄60岁、化疗、CA199≤37IU/ml、CEA≤5ng/ml、手术等5个因素是可以延长晚期结直肠癌的总生存时间；手术加上射频的患者能够获得更好的近期疗效；三种手术方式中,原发灶切除+转移灶切除患者的预后更好。
[Abstract]:Objective: to analyze the factors affecting the curative effect and prognosis of patients with advanced colorectal cancer. Methods: the data of 222 patients with advanced colorectal cancer admitted from January 2004 to December 2014 were retrospectively reviewed and followed up. Log-rank method (univariate analysis) and Cox model (multivariate analysis) were used to analyze the correlation between these factors and prognosis. Results: (1) there was a significant correlation between age, operation, chemotherapy, CEA,CA199 and overall survival time, including age, operation and chemotherapy. (2) Age, chemotherapy and CA199, CEA, operation were the main factors influencing the prognosis of advanced colorectal cancer, among which CEA and operation mode were significantly affected. (3) the survival time of the patients undergoing operation was significantly longer than that of the patients without operation, among which the total survival time of the patients with primary tumor resection and metastasis resection was significantly longer than that of the patients without operation, and the total survival time of the patients with primary tumor resection and palliative surgery was significantly longer than that of the patients without operation. Patients who received surgery plus radiofrequency had better short-term outcomes than patients with surgery alone. Conclusion: the age of 60 years old, chemotherapy, CA199 37 IU / ml,CEA 鈮，

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