结肠癌根治术后肠道菌群及益生菌干预对结肠癌预后的影响
发布时间：2019-05-14 12:48
【摘要】：目的考察结肠癌根治术后肠道菌群与结肠癌预后的关系,以及益生菌干预对结肠癌预后的影响。方法收集2010年4月至2013年4月在我院收治并确诊的Ⅱ期结肠癌患者185例,患者均接受根治术,按照实际接受的治疗方案分为益生菌干预组(80例)和益生菌未干预组(105例),选择同期健康体检者20例为对照组。收集术前和术后1个月粪便,采用荧光定量PCR检测粪便的乳酸杆菌属、双歧杆菌属、大肠杆菌和肠球菌属。分析结肠癌患者术后4年生存情况及与肠道菌群数量的关系。结果两组术前双歧杆菌属、乳酸杆菌属、大肠杆菌和肠球菌属差异无统计学意义(P0.05),根治术后,双歧杆菌属、乳酸杆菌属、双歧杆菌属、大肠杆菌和肠球菌属均明显降低(P0.05),益生菌干预组和益生菌未干预组的菌群术前、术后差异均无统计学意义(P0.05)。4年随访,无1例失访。105例益生菌未干预组中存活90例(85.71%),15例(14.29%)死亡,其中14例为结肠癌转移死亡,1例为心血管病死亡。乳酸杆菌属(χ~2=6.700,P=0.035)和双歧杆菌属(χ~2=5.777,P=0.016)数量越高,大肠杆菌(χ~2=3.301,P=0.069)和肠球菌属(χ~2=4.780,P=0.029)数量越低,结肠癌患者4年生存时间越长。80例益生菌干预组中存活76例(95.00%),4例(5.00%)患者死亡,其中3例为结肠癌转移死亡,1例交通意外死亡。与益生菌未干预组比较,益生菌干预组的存活例数较多(χ~2=4.248,P=0.039),因结肠癌转移死亡例数较少(χ~2=4.997,P=0.025)。结论结肠癌根治术后,双歧杆菌属和乳酸杆菌属数量越高,大肠杆菌和肠球菌属数量越低,结肠癌的预后较好。给予益生菌干预可明显改善结肠癌根治术后患者的生存情况。
[Abstract]:Objective to investigate the relationship between intestinal flora and prognosis of colon cancer after radical resection of colon cancer, and the effect of probiotic intervention on prognosis of colon cancer. Methods 185 patients with stage II colon cancer admitted and diagnosed in our hospital from April 2010 to April 2013 were collected and divided into probiotics intervention group (80 cases) and probiotics non-intervention group (105 cases) according to the actual treatment plan. Twenty cases of healthy physical examination in the same period were selected as the control group. The feces were collected before and 1 month after operation, and Lactobacillus, bifidobacillus, Escherichia coli and Enterococcus were detected by fluorescence quantitative PCR. The survival rate of colon cancer patients at 4 years after operation and the relationship between survival and intestinal flora were analyzed. Results there was no significant difference in Bifidobacillus, Lactobacillus, Escherichia coli and Enterococcus between the two groups before operation (P 0.05). After radical operation, Bifidobacillus, Lactobacillus, Bifidobacillus, Escherichia coli and Enterococcus decreased significantly (P 0.05), and there was no significant difference between probiotics intervention group and probiotic non-intervention group before and after operation (P 0.05). 4 years follow-up, In 105 cases of probiotic unintervention group, 90 cases (85.71%) survived and 15 cases (14.29%) died, including 14 cases of colon cancer metastasis and 1 case of cardiovascular disease. The higher the number of Lactobacillus (蠂 ~ 2 鈮，
本文编号：2476731
[Abstract]:Objective to investigate the relationship between intestinal flora and prognosis of colon cancer after radical resection of colon cancer, and the effect of probiotic intervention on prognosis of colon cancer. Methods 185 patients with stage II colon cancer admitted and diagnosed in our hospital from April 2010 to April 2013 were collected and divided into probiotics intervention group (80 cases) and probiotics non-intervention group (105 cases) according to the actual treatment plan. Twenty cases of healthy physical examination in the same period were selected as the control group. The feces were collected before and 1 month after operation, and Lactobacillus, bifidobacillus, Escherichia coli and Enterococcus were detected by fluorescence quantitative PCR. The survival rate of colon cancer patients at 4 years after operation and the relationship between survival and intestinal flora were analyzed. Results there was no significant difference in Bifidobacillus, Lactobacillus, Escherichia coli and Enterococcus between the two groups before operation (P 0.05). After radical operation, Bifidobacillus, Lactobacillus, Bifidobacillus, Escherichia coli and Enterococcus decreased significantly (P 0.05), and there was no significant difference between probiotics intervention group and probiotic non-intervention group before and after operation (P 0.05). 4 years follow-up, In 105 cases of probiotic unintervention group, 90 cases (85.71%) survived and 15 cases (14.29%) died, including 14 cases of colon cancer metastasis and 1 case of cardiovascular disease. The higher the number of Lactobacillus (蠂 ~ 2 鈮，
本文编号：2476731
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