Ⅰ期非小细胞肺癌GRP94和淋巴结微转移与预后相关性分析
发布时间：2019-05-15 11:13
【摘要】：目的肺癌的局部淋巴结微转移是肺癌患者术后复发的重要原因。本研究探讨葡萄糖调节蛋白94(glucose regulated protein 94,GRP94)和非小细胞肺癌(non-small cell lung cancer,NSCLC)之间的联系及GRP94在Ⅰ期NSCLC患者淋巴结中表达情况与患者预后的相关性,为患者的术后治疗提供理论依据。方法采用免疫组化(immunohistochemical,IHC)法检验2011-02-01-2014-01-31佳木斯大学附属第一医院胸外科54例Ⅰ期NSCLC组织及10例肺良性病变患者正常肺组织GRP94的表达;IHC法检验所选54例Ⅰ期的NSCLC患者及10例肺良性病变患者的肺门(N1)淋巴结、隆突下(N2)淋巴结中GRP94表达情况;随访所选54例患者预后(无癌生存时间)。结果54例患者癌组织中GRP94阳性表达率为100%(54/54),10例正常肺组织中无GRP94表达,差异有统计学意义,χ~2=56.640,P0.001。108枚肺癌患者淋巴结中有22枚GRP94表达阳性,20枚正常淋巴中GRP94未见表达,差异有统计学意义,χ~2=3.593,P=0.058。8例N1淋巴结GRP94阳性表达患者与36例淋巴结中未见GRP94表达患者生存曲线对比,差异无统计学意义,χ~2=0.264,P=0.608。6例N2淋巴结GRP94阳性表达患者与36例淋巴结中未见GRP94表达,患者生存曲线对比,差异有统计学意义,χ~2=7.282,P=0.007。多因素分析显示,N2淋巴结微转移是Ⅰ期NSCLC患者预后不良危险因素,P=0.008。结论 GRP94与肺癌的发生发展具有一定的相关性,N2淋巴结微转移的患者对比不存在N2淋巴结微转移的患者,生存率显著降低。N2淋巴结微转移是Ⅰ期NSCLC患者预后较差危险因素。
[Abstract]:Objective Local lymph node micrometastasis of lung cancer is an important cause of postoperative recurrence of lung cancer. The aim of this study was to investigate the relationship between glucose regulated protein 94 (glucose regulated protein 94, GRP94 and non small cell lung cancer (non-small cell lung cancer,NSCLC) and the correlation between the expression of GRP94 in lymph nodes of patients with stage I NSCLC and prognosis. It provides a theoretical basis for the postoperative treatment of patients. Methods Immunohistochemical (immunohistochemical,IHC) method was used to detect the expression of GRP94 in 54 cases of stage I NSCLC and 10 cases of normal lung tissue in the first affiliated Hospital of Jiamusi University. IHC method was used to detect the expression of GRP94 in hilar (N1) lymph nodes and subprotruding (N2) lymph nodes in 54 patients with stage I NSCLC and 10 patients with benign pulmonary lesions, and the prognosis (cancer-free survival time) of 54 patients was followed up. Results the positive expression rate of GRP94 was 100% (54 鈮，
本文编号：2477460
[Abstract]:Objective Local lymph node micrometastasis of lung cancer is an important cause of postoperative recurrence of lung cancer. The aim of this study was to investigate the relationship between glucose regulated protein 94 (glucose regulated protein 94, GRP94 and non small cell lung cancer (non-small cell lung cancer,NSCLC) and the correlation between the expression of GRP94 in lymph nodes of patients with stage I NSCLC and prognosis. It provides a theoretical basis for the postoperative treatment of patients. Methods Immunohistochemical (immunohistochemical,IHC) method was used to detect the expression of GRP94 in 54 cases of stage I NSCLC and 10 cases of normal lung tissue in the first affiliated Hospital of Jiamusi University. IHC method was used to detect the expression of GRP94 in hilar (N1) lymph nodes and subprotruding (N2) lymph nodes in 54 patients with stage I NSCLC and 10 patients with benign pulmonary lesions, and the prognosis (cancer-free survival time) of 54 patients was followed up. Results the positive expression rate of GRP94 was 100% (54 鈮，
本文编号：2477460
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