乳腺癌中HPA、E-cadherin表达的相关性及其意义
发布时间：2019-05-17 16:42
【摘要】：目的:检测乳腺癌组织、正常乳腺组织中HPA和E-cad的表达情况并结合乳腺癌临床病理特征,分析二者在乳腺癌发生发展中的作用及相关性。方法:研究采用免疫组织化学SABC法,收集女性患者乳腺癌标本60例,另取其对应癌旁正常乳腺组织标本作为对照,检测HPA和E-cad在上述组织标本中的表达情况,结合乳腺癌相关临床病理因素,研究二者在乳腺癌组织中的表达与乳腺癌其他生物学特点之间的关系。结果:1.乳腺癌组织和癌旁正常乳腺组织中HPA的阳性表达率,二者分别为68.3%和13.2%,差异显著有统计学意义(P0.05);2.乳腺癌组织和癌旁正常乳腺组织中E-cad的阳性表达率,二者分别为33.3%和95.0%,差异显著有统计学意义(P0.05);3.HPA的表达与组织病理学分级、TNM分期及淋巴结转移明显相关(P0.05),而与肿瘤大小、患者年龄无明显相关(P0.05);E-cad的表达与组织病理学分级、肿瘤TNM分期以及淋巴结转移明显相关(P0.05),而与肿瘤大小、患者年龄无明显相关(P0.05);4.在乳腺癌中,HPA和E-cad的阳性表达率呈明显的负相关(r=㧟0.47,P0.05)。结论:1.相较于正常乳腺组织,HPA在乳腺癌组织中表达水平明显升高,且与肿瘤组织病理学分级、TNM分期及淋巴结转移明显相关(P0.05)。2.相较于正常乳腺组织,E-cad在乳腺癌组织中表达水平明显降低,且与肿瘤组织病理学分级、TNM分期以及淋巴结转移明显相关(P0.05)。3.乳腺癌组织中HPA与E-cad的表达存在负相关性;HPA升高与E-cad减少共同促进肿瘤发展和转移;联合检测具有一定的意义。
[Abstract]:Objective: To study the expression of HPA and E-cad in breast cancer tissues and normal breast tissues and to analyze the role and correlation of both breast cancer and breast cancer in the development of breast cancer. Methods: The expression of HPA and E-cad in the above-mentioned tissue specimens was detected by immunohistochemical SABC method, and the expression of HPA and E-cad in the above-mentioned tissue specimens was detected. The relationship between the expression of both breast cancer and other biological characteristics of breast cancer was studied. Results:1. The positive expression rates of HPA in breast and adjacent normal breast tissues were 68.3% and 13.2%, respectively. The positive rate of E-cad in breast and adjacent normal breast tissues was 33.3% and 95.0%, respectively, and the difference was statistically significant (P0.05);3. The expression of HPA was correlated with the histological grade, TNM stage and lymph node metastasis (P0.05). There was no significant correlation between the age of the patients (P0.05); the expression of E-cad was related to the histological grade, TNM stage and lymph node metastasis (P0.05), but not related to the size of the tumor and the age of the patients (P0.05); In breast cancer, the positive expression of HPA and E-cad was negatively correlated (r =-0.47, P0.05). Conclusion:1. Compared with normal breast tissue, the expression level of HPA in breast cancer tissue was significantly increased, and it was associated with the pathological grade, TNM stage and lymph node metastasis of the tumor (P0.05). Compared with normal breast tissue, the expression of E-cad in breast cancer tissue was significantly lower, and it was associated with the pathological grade, TNM stage and lymph node metastasis of the tumor (P0.05). The expression of HPA and E-cad in breast cancer tissue has negative correlation, and the increase of HPA and E-cad can promote the development and metastasis of the tumor.
【学位授予单位】：蚌埠医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R737.9
本文编号：2479252
[Abstract]:Objective: To study the expression of HPA and E-cad in breast cancer tissues and normal breast tissues and to analyze the role and correlation of both breast cancer and breast cancer in the development of breast cancer. Methods: The expression of HPA and E-cad in the above-mentioned tissue specimens was detected by immunohistochemical SABC method, and the expression of HPA and E-cad in the above-mentioned tissue specimens was detected. The relationship between the expression of both breast cancer and other biological characteristics of breast cancer was studied. Results:1. The positive expression rates of HPA in breast and adjacent normal breast tissues were 68.3% and 13.2%, respectively. The positive rate of E-cad in breast and adjacent normal breast tissues was 33.3% and 95.0%, respectively, and the difference was statistically significant (P0.05);3. The expression of HPA was correlated with the histological grade, TNM stage and lymph node metastasis (P0.05). There was no significant correlation between the age of the patients (P0.05); the expression of E-cad was related to the histological grade, TNM stage and lymph node metastasis (P0.05), but not related to the size of the tumor and the age of the patients (P0.05); In breast cancer, the positive expression of HPA and E-cad was negatively correlated (r =-0.47, P0.05). Conclusion:1. Compared with normal breast tissue, the expression level of HPA in breast cancer tissue was significantly increased, and it was associated with the pathological grade, TNM stage and lymph node metastasis of the tumor (P0.05). Compared with normal breast tissue, the expression of E-cad in breast cancer tissue was significantly lower, and it was associated with the pathological grade, TNM stage and lymph node metastasis of the tumor (P0.05). The expression of HPA and E-cad in breast cancer tissue has negative correlation, and the increase of HPA and E-cad can promote the development and metastasis of the tumor.
【学位授予单位】：蚌埠医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R737.9
【参考文献】
相关期刊论文 前5条
1 郑瑾;刘强;史恒军;任秦有;杨建刚;刘新平;刘文超;;NDRG2通过影响CD24调控乳腺癌细胞的粘附能力[J];现代生物医学进展;2012年01期
2 江宁;刘学武;刘文超;刘新平;;用比较基因组学方法分析人NDRG2的生物学功能[J];第四军医大学学报;2009年18期
3 朱财林;李南林;王廷;王岭;;NDRG2对乳腺癌细胞增殖的影响[J];第四军医大学学报;2009年11期
4 张文红,刘新平,王琰,韩月恒,药立波;Ndrg2基因及NDRG2蛋白的生物信息学分析[J];第四军医大学学报;2003年17期
5 邓艳春,药立波,刘新平,聂晓燕,王吉村,张晓光,苏成芝;人脑内一含有ACP样结构域新基因的发现[J];生物化学与生物物理进展;2001年01期
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