肠道菌群通过脑肠轴影响肿瘤的发生发展
发布时间：2019-05-22 16:05
【摘要】：正常情况下,人体肠道内菌群保持相对稳定的状态,共生菌、益生菌和病原菌的比例维持相对稳定。肠道菌群失调可改变肠道内的生理环境,还能通过各种途径引起人体肠外组织器官生理状态的改变,甚至影响肿瘤的发生发展。脑肠轴是其中一条通路,由免疫、代谢、神经内分泌和迷走神经等途径构成。本文旨在讨论肿瘤和肠道菌群之间的关系以及肠道菌群通过脑肠轴的4条途径改变机体的应激水平,从而影响肿瘤发生发展的相关机制,同时就肠道菌群调控在肿瘤治疗中的作用进行了探讨。
[Abstract]:Under normal conditions, the intestinal flora of the human body is kept relatively stable, and the proportion of the symbiotic bacteria, the probiotics and the pathogenic bacteria is maintained relatively stable. The intestinal flora imbalance can change the physiological environment in the intestinal tract, and can cause the change of the physiological state of the organs and organs of the human body through various ways, and even influence the development of the tumor. The brain-intestinal axis is one of the pathways, which is composed of the routes of immunity, metabolism, neuroendocrine and vagus nerve. The purpose of this paper is to discuss the relationship between the intestinal flora and the intestinal flora, and to change the stress level of the body through the four ways of the brain-intestinal axis, so as to influence the mechanism of the development of the tumorigenesis, and also discuss the role of the intestinal flora regulation in the treatment of the tumor.
【作者单位】： 复旦大学附属妇产科医院中西医结合科;
【基金】：国家自然科学基金项目(编号:81472423) 上海市科委基金项目(编号:14430723000)资助~~
【分类号】：R730.2
本文编号：2483052
[Abstract]:Under normal conditions, the intestinal flora of the human body is kept relatively stable, and the proportion of the symbiotic bacteria, the probiotics and the pathogenic bacteria is maintained relatively stable. The intestinal flora imbalance can change the physiological environment in the intestinal tract, and can cause the change of the physiological state of the organs and organs of the human body through various ways, and even influence the development of the tumor. The brain-intestinal axis is one of the pathways, which is composed of the routes of immunity, metabolism, neuroendocrine and vagus nerve. The purpose of this paper is to discuss the relationship between the intestinal flora and the intestinal flora, and to change the stress level of the body through the four ways of the brain-intestinal axis, so as to influence the mechanism of the development of the tumorigenesis, and also discuss the role of the intestinal flora regulation in the treatment of the tumor.
【作者单位】： 复旦大学附属妇产科医院中西医结合科;
【基金】：国家自然科学基金项目(编号:81472423) 上海市科委基金项目(编号:14430723000)资助~~
【分类号】：R730.2
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