红细胞体积分布宽度、乳腺癌分子标志物与乳腺癌病变程度的相关性研究
发布时间：2019-05-24 17:35
【摘要】：目的:通过观察乳腺癌患者红细胞体积分布宽度(RDW)和乳腺癌分子标志物即雌激素受体(ER)、孕激素受体(PR)及人类表皮生长因子受体2(HER-2)指标的变化,探讨其与乳腺癌病变程度的关系及临床意义。方法:收集2011年1月至2015年7月在兰州大学第一医院收治并经空芯针穿刺活检或术后病理诊断为乳腺癌患者的临床资料,进行回顾性分析,完整记录患者的临床基线资料、红细胞参数、生化指标以及乳腺癌分子标志物检查结果。选取体检的健康女性作为正常对照组。应用SPSS 21.0软件进行统计学分析,将乳腺癌组与正常对照组及乳腺癌亚组之间的红细胞参数和生化指标进行比较,同时对比各亚组间乳腺癌分子标志物是否存在差异,用Logistic回归分析评估乳腺癌腋窝淋巴结转移的影响因素。结果:1.本研究共纳入了87例女性乳腺癌患者,按组织学分类分组:包括浸润性导管癌76例(87.36%),浸润性小叶癌8例(9.20%),黏液癌3例(3.45%);按组织学分级分组:包括Ⅰ~Ⅱ期48例(55.17%),Ⅲ期33例(37.93%),Ⅳ期6例(6.90%);按腋窝淋巴结转移与否分组,伴腋窝淋巴结转移36例(41.38%),不伴腋窝淋巴结转移51例(58.62%)。2.乳腺癌组的Hb和Alb明显低于正常对照组(P0.05),而MCV、RDW和LDL明显高于正常对照组(P0.05)。乳腺癌亚组中,伴腋窝淋巴结转移组Hb明显低于不伴腋窝淋巴结转移组(P0.05),而MCV、RDW明显高于不伴腋窝淋巴结转移组(P0.05)。Ⅲ期、Ⅳ期RDW明显高于Ⅰ~Ⅱ期,而Ⅳ期RDW明显高于Ⅲ期(P0.05)。3.HER-2阳性表达率与乳腺癌腋窝淋巴结转移与否具有显著差异性(P0.05)。HER-2阳性表达组的RDW明显高于阴性表达组;HER-2阳性表达的乳腺癌患者伴腋窝淋巴结转移组的RDW明显高于不伴腋窝淋巴结转移组(P0.05)。4.Hb和MCV是乳腺癌腋窝淋巴结转移的保护因子,而RDW和HER-2是危险因子。且随着RDW值升高,其每相差一个等级,乳腺癌患者发生腋窝淋巴结转移的危险增加1.255倍;HER-2阳性表达的乳腺癌患者发生腋窝淋巴结转移的可能性是HER-2阴性表达者的2.094倍。结论:1.浸润性导管癌(非特殊型浸润性癌)是乳腺癌中最常见的类型。2.RDW升高可作为评估乳腺癌预后的指标之一。3.RDW和HER-2联合分析,可作为评估乳腺癌腋窝淋巴结转移的预测指标。4.RDW和HER-2水平有望作为乳腺癌腋窝淋巴结转移的独立预测因素。
[Abstract]:Objective: to observe the changes of erythrocyte volume distribution width (RDW) and breast cancer molecular marker estrogen receptor (ER), progesterone receptor (PR) and human epidermis growth factor receptor 2 (HER-2) in patients with breast cancer. To explore the relationship between breast cancer and the degree of breast cancer and its clinical significance. Methods: from January 2011 to July 2015, the clinical data of patients with breast cancer diagnosed by hollow needle biopsy or postoperative pathology in the first Hospital of Lanzhou University were collected and analyzed retrospectively. the clinical baseline data of the patients were recorded completely. Red blood cell parameters, biochemical indexes and breast cancer molecular markers. Healthy women were selected as normal control group. The erythrocyte parameters and biochemical indexes between breast cancer group and normal control group and breast cancer subgroup were compared by SPSS 21.0 software, and the differences of breast cancer molecular markers among each subgroup were compared at the same time. Logistic regression analysis was used to evaluate the influencing factors of axillary lymph node metastasis in breast cancer. Result: 1. A total of 87 female patients with breast cancer were classified according to histology: 76 cases (87.36%) were invasive ductal carcinoma, 8 cases (9.20%) were invasive lobular carcinoma and 3 cases (3.45%) were mucinous carcinoma. According to the histological grade, there were 48 cases (55.17%) in stage 鈪，
本文编号：2485052
[Abstract]:Objective: to observe the changes of erythrocyte volume distribution width (RDW) and breast cancer molecular marker estrogen receptor (ER), progesterone receptor (PR) and human epidermis growth factor receptor 2 (HER-2) in patients with breast cancer. To explore the relationship between breast cancer and the degree of breast cancer and its clinical significance. Methods: from January 2011 to July 2015, the clinical data of patients with breast cancer diagnosed by hollow needle biopsy or postoperative pathology in the first Hospital of Lanzhou University were collected and analyzed retrospectively. the clinical baseline data of the patients were recorded completely. Red blood cell parameters, biochemical indexes and breast cancer molecular markers. Healthy women were selected as normal control group. The erythrocyte parameters and biochemical indexes between breast cancer group and normal control group and breast cancer subgroup were compared by SPSS 21.0 software, and the differences of breast cancer molecular markers among each subgroup were compared at the same time. Logistic regression analysis was used to evaluate the influencing factors of axillary lymph node metastasis in breast cancer. Result: 1. A total of 87 female patients with breast cancer were classified according to histology: 76 cases (87.36%) were invasive ductal carcinoma, 8 cases (9.20%) were invasive lobular carcinoma and 3 cases (3.45%) were mucinous carcinoma. According to the histological grade, there were 48 cases (55.17%) in stage 鈪，
本文编号：2485052
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