TOP2α过表达与R0术后胃癌患者临床病理特征及预后关系

发布时间：2019-05-26 23:03

【摘要】：目的:已有研究证实探讨拓扑异构酶2α(TOP2α)过表达与实体肿瘤的临床病理特征及预后相关。然而少有研究报道TOP2α过表达与胃癌临床病理特征及预后关联。本研究目的探讨TOP2α过表达与胃癌患者病理特征之间的关系,以及对胃癌患者预后的影响。方法:收集2009年12月到2011年12月就诊于四家医院的胃癌患者。这些患者均行R0切除术,术后留取胃癌患者病理组织,将组织于福尔马林溶液中浸泡、石蜡包埋后切片。通过电话及院内、院外门诊系统对所有纳入研究的胃癌患者进行随访。TOP2α过表达与患者临床病理特征、整体预后以及接受术后化疗的患者预后之间的关系。结果:TOP2α过表达与肿瘤位置(P0.001)、肿瘤浸润深度(P=0.002)、以及pTNM分期(P=0.002)等临床病理特征相关。TOP2α过表达与患者的其他临床病理特征无相关性,包括性别(P=0.199),年龄(P=0.459),肿瘤分化程度(P=0.071)、淋巴结转移分级(P=0.192),淋巴、血管浸润(P=0.382),神经浸润(P=0.382)。单因素及多因素分析均提示:在小于或等于60岁的非贲门胃癌患者中,TOP2α过表达患者有更差的5年总生存时间(P=0.023)。在小于或等于60岁接受术后化疗的非贲门胃癌患者中,TOP2α过表达患者同样预示更差的5年总生存时间(P=0.048)。结论:TOP2α过表达与肿瘤位置、肿瘤浸润深度、以及pTNM分期等临床病理特征有相关性。在小于或等于60岁非贲门胃癌患者中,TOP2α过表达提示较差的5年总生存时间。在小于或等于60岁非贲门且接受术后化疗的胃癌患者中,TOP2α过表达同样提示较差的5年总生存时间。
[Abstract]:Objective: to investigate the relationship between topoisomer 2 伪 (TOP2 伪) overexpression and clinicopathological features and prognosis of solid tumors. However, few studies have reported that the overexpression of TOP2 伪 is associated with clinicopathological features and prognosis of gastric cancer. The purpose of this study was to investigate the relationship between overexpression of TOP2 伪 and pathological features of patients with gastric cancer, and its effect on prognosis of patients with gastric cancer. Methods: from December 2009 to December 2011, patients with gastric cancer were collected from four hospitals. All of these patients underwent R0 resection. After operation, the pathological tissues of patients with gastric cancer were taken and immersed in formalin solution. All patients with gastric cancer included in the study were followed up by telephone and in-hospital and out-of-hospital outpatient system. the relationship between TOP2 伪 overexpression and clinicopathological features, overall prognosis and prognosis of patients receiving postoperative chemotherapy. Results: the overexpression of TOP2 伪 was correlated with the clinicopathological features such as tumor location (P0.001), depth of tumor invasion (P 鈮，

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