非转移性结直肠癌组织中MMR的表达状态及意义
发布时间：2019-05-30 05:06
【摘要】：目的观察错配修复基因(MMR)在非转移性结直肠组织中的表达状态并探讨其意义。方法选取141例接受手术治疗的非转移性结直肠癌患者,均未接受术前放疗或化疗。术后病理标本进行常规病理检测及免疫组化法检测4种MMR蛋白(MLH1、MSH2、MSH6、PMS2)表达。四种蛋白中一种及以上不表达,即判定为MMR表达缺失(d MMR),对比MMR正常和d MMR结直肠癌患者的临床病理特征。结果非转移性结直肠癌患者的MLH1、MSH2、MSH6、PMS2表达缺失率分别为15.6%(22/141)、2.8%(4/141)、7.1%(10/141)、15.6%(22/141),d MMR率为25.5%(36/141)。MMR表达与非转移性结直肠癌患者年龄、部位、肿瘤大小及病理类型等有关(P均0.05),d MMR更多发生于60岁以下、近端部位、黏液类型癌及较大的肿瘤(P均0.05)。结论非转移性结直肠癌患者癌组织中MMR表达存在缺失,MMR状态的评估有助于判断患者预后和指导治疗。
[Abstract]:Objective to observe the expression of mismatch repair gene (MMR) in non-metastatic colorectal tissues and to explore its significance. Methods 141 patients with non-metastatic colorectal cancer who underwent surgical treatment were not treated with preoperative radiotherapy or chemotherapy. The expression of four kinds of MMR proteins (MLH1,MSH2,MSH6,PMS2) was detected by routine pathological examination and immunohistochemistry in postoperative pathological specimens. One or more of the four proteins were not expressed, that is to say, the loss of MMR expression (d MMR), was compared with the clinicopathological features of MMR normal and d MMR colorectal cancer patients. Results the deletion rate of MLH1,MSH2,MSH6,PMS2 expression in patients with non-metastasis colorectal cancer was 15.6% (22 鈮，
本文编号：2488549
[Abstract]:Objective to observe the expression of mismatch repair gene (MMR) in non-metastatic colorectal tissues and to explore its significance. Methods 141 patients with non-metastatic colorectal cancer who underwent surgical treatment were not treated with preoperative radiotherapy or chemotherapy. The expression of four kinds of MMR proteins (MLH1,MSH2,MSH6,PMS2) was detected by routine pathological examination and immunohistochemistry in postoperative pathological specimens. One or more of the four proteins were not expressed, that is to say, the loss of MMR expression (d MMR), was compared with the clinicopathological features of MMR normal and d MMR colorectal cancer patients. Results the deletion rate of MLH1,MSH2,MSH6,PMS2 expression in patients with non-metastasis colorectal cancer was 15.6% (22 鈮，
本文编号：2488549
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