肺内磨玻璃密度影良恶性判别的多因素logistic回归分析

发布时间：2019-06-22 15:11

【摘要】：目的:通过对病理确诊的105例肺内磨玻璃影患者其临床特点、CT图像及结果,研究肺内磨玻璃密度影良、恶性的危险因素。方法:根据纳入、排除标准筛选出本院经病理确诊的肺内磨玻璃密度影患者105例,回顾分析其临床资料及影像学特点,运用统计工具SPSS19,对选择的12个主要影响肺内磨玻璃密度影良恶性临床鉴别的因素进行单因素及多因素的回归分析。结果:本组105例患者中,恶性肿瘤患者63例(60%),良性病变患者42例(40%)。单因素统计数据显示吸烟指数、年龄、G GO面积、周围毛刺征、边缘分叶征、胸膜凹陷征、亨氏单位(Hounsfield units,HU)值7个因素对临床鉴别肺内磨玻璃样密度影良、恶性有意义(P0.05)。多因素Logistic回归结果患者年龄(OR=1.066,95%CI:1.020~1.114,P=0.000)、周围分叶(OR=4.419,95%CI:1.388~14.077,P=0.000)、周围毛刺(OR=4.098,95%CI:1.401~11.987,P=0.000)。结论:根据统计分析及随访结果,故认为患者年龄及CT影像学中边缘分叶征、周围毛刺征对临床诊断肺内磨玻璃样密度影的良恶性有重要的指导意义,可以进一步外科处理。
[Abstract]:Objective: to study the risk factors of benign and malignant intrapulmonary ground glass density by analyzing the clinical features, CT images and results of 105 patients with intrapulmonary glass grinding. Methods: according to the inclusion and exclusion criteria, 105 patients with pulmonary ground glass density diagnosed pathologically in our hospital were screened out. The clinical data and imaging features were analyzed retrospectively. the single factor and multivariate regression analysis of the 12 factors that mainly affected the clinical differentiation of benign and malignant pulmonary grinding glass density shadow was carried out by using statistical tool SPSS19,. Results: among 105 patients, 63 (60%) were malignant tumors and 42 (40%) were benign lesions. Univariate statistical data showed that smoking index, age, G GO area, peripheral burr sign, marginal lobulation sign, pleural indentation sign and Heinz unit (Hounsfield units,HU) value were significant for clinical differentiation of pulmonary ground glass density between benign and malignant (P 0.05). Multivariate Logistic regression results included age (OR=1.066,95%CI:1.020~1.114,P=0.000), peripheral lobulation (OR=4.419,95%CI:1.388~14.077,P=0.000) and peripheral burr (OR=4.098,95%CI:1.401~11.987,P=0.000). Conclusion: according to the statistical analysis and follow-up results, it is considered that the age of the patients and the marginal lobulation sign in CT imaging and peripheral burr sign are of great significance in the clinical diagnosis of benign and malignant ground glass density shadow in the lung, and can be further treated surgically.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2

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