隐源性肝癌的临床特点及病理特征分析

发布时间：2019-07-05 11:02

【摘要】：目的通过对隐源性肝癌临床特点及病理特征分析,进一步寻找其病因及发病机制。方法选择2010年1月~(-2)015年12月于吉林大学中日联谊医院行手术治疗的隐源性肝癌患者22例,对其年龄、性别、临床表现、肝生化指标、肿瘤标志物、病理及免疫组化等资料进行分析。结果隐源性肝癌患者平均57岁,男女比例约为1.7∶1。伴有脂肪肝患者16例,占72.7%。有临床症状者13例,占59.1%,主要表现为腹痛、腹胀等。生化检查异常以ALP和(或)GGT升高为主,共14例,占63.6%。病理结果显示,以胆管细胞癌为主,共16例,占72.7%;肿瘤多为单发,共20例,占90.9%;肿瘤直径多5 cm,共14例,占63.6%;伴局部浸润4例,占18.2%;伴脉管浸润2例,占9.1%。免疫组化结果显示,Ki67阳性患者为19例,CK17阳性13例,CK19阳性16例。结论通过对隐源性肝癌患者的临床及病理特点进行分析,可明确非酒精性脂肪性肝炎是隐源性肝癌的主要致病因素之一,且因其引起的肝癌多为单发腺癌。
[Abstract]:Objective To find out the causes and pathogenesis of cryptogenic liver cancer. Methods 22 cases of cryptogenic liver cancer were selected from January 2010 to December (-2) and December,015 in Jilin University. The age, sex, clinical manifestation, liver biochemical index, tumor marker, pathology and immunohistochemistry were analyzed. Results The average age of the patients with cryptogenic liver cancer was 57 years and the ratio of male to female was about 1.7:1. 16 patients with fatty liver accounted for 72.7%. There were 13 patients with clinical symptoms (59.1%), mainly including abdominal pain, abdominal distention, etc. The level of ALP and/ or GGT was mainly increased in 14 cases, accounting for 63.6%. The results showed that there were 16 cases (72.7%) of the common bile duct cell carcinoma (72.7%), the tumors were single,20 cases (90.9%), the tumor diameter was 5 cm, the total was 14 cases (63.6%), with the local infiltration in 4 cases (18.2%), and with the vessel infiltration in 2 cases (9.1%). The results showed that there were 19 cases of Ki67 positive patients,13 cases of CK17 and 16 cases of CK19. Conclusion The non-alcoholic steatohepatitis is one of the main pathogenic factors of the cryptogenic liver cancer by the analysis of the clinical and pathological characteristics of the patients with cryptogenic liver cancer.
【作者单位】：吉林大学中日联谊医院消化内科;吉林大学中日联谊医院神经内科;
【分类号】：R735.7

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