疏肝和胃穴位埋线法干预化疗延迟性呕吐的临床研究

发布时间：2019-07-08 15:16

【摘要】：目的:探讨疏肝和胃穴位埋线法对消化系肿瘤化疗所致的延迟性呕吐的临床疗效。方法:采用前瞻性临床随机对照方法。将60例使用中-高致吐风险化疗方案的消化系肿瘤患者,按数字随机法分为观察组和对照组,各30例。观察组以穴位埋线+西医止吐,对照组以单纯西医止吐。两组患者所用化疗药物均含有顺铂或蒽环类或奥沙利铂或氟尿嘧啶或紫杉醇等,具有中-高致吐风险。观察两组患者治疗后恶心呕吐的疗效差异。结果:1.在化疗前,观察组及对照组在性别、年龄、病种、肿瘤分期上基线一致,无明显统计学差异,两组患者具有可比性。2.在急性呕吐上,观察组与对照组呕吐发生率无统计学差异(93.33%vs.96.67%,p0.05);在延迟性呕吐上,化疗后d4~d6,观察组呕吐发生率分别为43.33%、50.00%、53.33%明显低于对照组60%、73.33%、76.66%,差异具有统计学意义(P0.05)。3.在控制恶心呕吐疗效上,观察组有效率为83.33%,明显优于对照组70%,具有统计学差异(P0.05)。4.治疗后,两组患者的KPS(健康状况)评分均较化疗前有所下降,观察组治疗前后无明显差异(P0.05),而对照组下降较明显(P0.05);即观察组健康状况状况明显优于对照组。5.治疗后,两组患者的QOL(生活质量)评分均较化疗前有所下降,观察组治疗前后无明显差异(P0.05),而对照组下降较明显(P0.05);即观察组生活质量状况明显优于对照组。结论:疏肝和胃穴位埋线法联合西医止吐药物在防治中-高致吐风险化疗所致的延迟性呕吐,明显优于单纯西医止吐方案,能够提高恶性肿瘤化疗期患者的健康状况及生活质量,值得临床广泛推广运用。
[Abstract]:Objective: To study the clinical effect of liver-soothing and stomach-point line-embedding method on the delayed vomiting induced by chemotherapy in the digestive system. Methods: A prospective, randomized, controlled method was used. 60 patients with digestive system with high-risk chemotherapy were divided into the observation group and the control group according to the digital random method. In the observation group, the point buried line + western medicine anti-vomiting, and the control group was treated with pure western medicine to stop vomiting. The chemotherapy drugs used in both groups contain cisplatin or carbocyclic or oxaliplatin or fluurine or paclitaxel or the like, and have moderate-high-to-discharge risk. The curative effect of nausea and vomiting after treatment was observed in two groups. Results:1. Before and after the chemotherapy, the baseline of sex, age, disease and tumor in the observation group and the control group were consistent and there was no significant statistical difference, and the two groups were comparable. The incidence of vomiting in the observation group and the control group was no statistical difference (93.33% vs. 96.67%, p0.05) in the case of acute vomiting, and the incidence of vomiting in the observation group was 43.33%, 50.00% and 53.33%, which was significantly lower than that of the control group, 73.33% and 76.66%, respectively. The difference was statistically significant (P0.05). In the treatment of nausea and vomiting, the effective rate of the observation group was 83.33%, which was significantly better than that of the control group (70%, P <0.05). After the treatment, the scores of KPS (health status) of the two groups were lower than that before chemotherapy, and there was no significant difference before and after the treatment (P0.05), and the control group had a significant decrease (P0.05); that is, the health status of the observation group was significantly better than that of the control group. The QOL (quality of life) of the two groups was lower than that of the control group after the treatment, and there was no significant difference before and after the treatment (P0.05), and the control group was significantly lower than that in the control group (P0.05). Conclusion: The delayed vomiting caused by the combination of the liver-soothing and the stomach-point line-embedding method in the prevention and treatment of the high-risk chemotherapy of the western medicine is superior to that of the simple western medicine anti-emetic scheme, and can improve the health status and the quality of life of the patients with the chemotherapy period of the malignant tumor, and is worthy of wide-scale popularization and application.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735

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