徐氏参芪苡术汤联合化疗治疗胃癌术后的疗效评价
发布时间：2019-07-10 12:26
【摘要】：目的:观察徐氏参芪苡术汤联合化疗对胃癌术后的临床症状、生活质量、化疗所致毒副反应等方面的影响,客观评价其疗效。方法:收集60例Ⅱ-Ⅲ期胃癌根治术后的患者,随机分成两组,各30例。对照组单纯给予化疗(XELOX或SOX方案),每个周期21天,观察4个周期;治疗组在化疗基础上服用徐氏参芪苡术汤,并随证加减,水煎服,每日早晚饭后一个半小时服用。化疗前2天和第四周期治疗结束后的1周内分别记录患者的临床症状、生活质量、体重、血常规、肝肾功能、消化道及神经系统副反应等情况。用SPSS19.0数据软件统计分析其结果,比较两组治疗前后的变化。结果:1.治疗后临床症状总积分治疗组低于对照组(P0.05),治疗组治疗后低于治疗前(P0.05),对照组治疗前后比较无统计学差异(P0.05)。治疗组胃脘痞胀、食少、便溏、乏力积分治疗后均低于治疗前(P0.05);对照组泛酸、便溏积分治疗后均高于治疗前(P0.05),便结积分治疗后低于治疗前(P0.05);治疗后,胃痛、胃脘痞胀、食少、泛酸、便溏、乏力积分治疗组均低于对照组(P0.05)。2.治疗后生活质量评分积分治疗组低于对照组(P0.05),治疗组治疗后低于治疗前(P0.05)。3.治疗后KPS评分治疗组高于对照组(P0.05),治疗组治疗后高于治疗前(P0.05),并且治疗组KPS评分疗效评价优于对照组(P0.05)。4.两组患者体重治疗前后、治疗组治疗前后变化均无统计学差异(P0.05),对照组治疗后低于治疗前(P0.05)。5.两组患者治疗后发生血液系统、肾功能、神经系统毒性例数比较无统计学差异(P0.05);但是发生恶心呕吐、腹泻例数治疗组少于对照组(P0.05)。结论:徐氏参芪苡术汤联合化疗可以改善患者胃痛、胃脘痞胀、食少、泛酸、便溏、乏力等方面的症状,改善机体功能状况,减轻化疗所致的恶心呕吐、腹泻等不良反应,提高胃癌术后患者的生活质量。
[Abstract]:Objective: to observe the effect of Xu's Shenqi Yizhu decoction combined with chemotherapy on the clinical symptoms, quality of life and side effects caused by chemotherapy in gastric cancer after operation, and to evaluate the curative effect objectively. Methods: sixty patients with stage II-III gastric cancer after radical resection were randomly divided into two groups with 30 cases each. The control group was given chemotherapy alone (XELOX or SOX regimen) for 21 days each cycle and observed 4 cycles, while the treatment group was treated with Xu's Shenqi Yizhu decoction on the basis of chemotherapy, which was taken one and a half hours after meals in the morning and evening. The clinical symptoms, quality of life, body weight, blood routine, liver and kidney function, digestive tract and nervous system side effects were recorded 2 days before chemotherapy and 1 week after the end of the fourth cycle of treatment. The results were statistically analyzed by SPSS19.0 software, and the changes of the two groups before and after treatment were compared. Result: 1. After treatment, the total score of clinical symptoms in the treatment group was lower than that in the control group (P 0.05), and that in the treatment group was lower than that before treatment (P 0.05). There was no significant difference in the control group before and after treatment (P 0.05). The treatment group epigastric distension, less food, loose stools, fatigue score after treatment were lower than before treatment (P 0.05); control group pan-acid, loose stool score after treatment were higher than before treatment (P 0.05), stool knot score after treatment was lower than before treatment (P 0.05); after treatment, stomach pain, epigastric distension, less food, pan-acid, loose stool, fatigue score were all lower than the control group (P 0.05). After treatment, the score of quality of life in the treatment group was lower than that in the control group (P 0.05), and that in the treatment group was lower than that before treatment (P 0.05). After treatment, the KPS score in the treatment group was higher than that in the control group (P 0.05), and that in the treatment group was higher than that before treatment (P 0.05), and the curative effect evaluation of KPS score in the treatment group was better than that in the control group (P 0.05). 4. There was no significant difference in body weight between the two groups before and after treatment (P 0.05), but it in the control group was lower than that before treatment (P 0.05). There was no significant difference in blood system, renal function and neurotoxicity between the two groups after treatment (P 0.05), but the number of nausea and vomiting and diarrhea in the treatment group was less than that in the control group (P 0.05). Conclusion: Xu's Shenqi Yizhu decoction combined with chemotherapy can improve the symptoms of stomachache, epigastric distension, less food, pan-acid, loose stool, fatigue and so on, improve the functional condition of the body, reduce the adverse reactions such as nausea, vomiting and diarrhea caused by chemotherapy, and improve the quality of life of patients with gastric cancer after operation.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.2
本文编号：2512608
[Abstract]:Objective: to observe the effect of Xu's Shenqi Yizhu decoction combined with chemotherapy on the clinical symptoms, quality of life and side effects caused by chemotherapy in gastric cancer after operation, and to evaluate the curative effect objectively. Methods: sixty patients with stage II-III gastric cancer after radical resection were randomly divided into two groups with 30 cases each. The control group was given chemotherapy alone (XELOX or SOX regimen) for 21 days each cycle and observed 4 cycles, while the treatment group was treated with Xu's Shenqi Yizhu decoction on the basis of chemotherapy, which was taken one and a half hours after meals in the morning and evening. The clinical symptoms, quality of life, body weight, blood routine, liver and kidney function, digestive tract and nervous system side effects were recorded 2 days before chemotherapy and 1 week after the end of the fourth cycle of treatment. The results were statistically analyzed by SPSS19.0 software, and the changes of the two groups before and after treatment were compared. Result: 1. After treatment, the total score of clinical symptoms in the treatment group was lower than that in the control group (P 0.05), and that in the treatment group was lower than that before treatment (P 0.05). There was no significant difference in the control group before and after treatment (P 0.05). The treatment group epigastric distension, less food, loose stools, fatigue score after treatment were lower than before treatment (P 0.05); control group pan-acid, loose stool score after treatment were higher than before treatment (P 0.05), stool knot score after treatment was lower than before treatment (P 0.05); after treatment, stomach pain, epigastric distension, less food, pan-acid, loose stool, fatigue score were all lower than the control group (P 0.05). After treatment, the score of quality of life in the treatment group was lower than that in the control group (P 0.05), and that in the treatment group was lower than that before treatment (P 0.05). After treatment, the KPS score in the treatment group was higher than that in the control group (P 0.05), and that in the treatment group was higher than that before treatment (P 0.05), and the curative effect evaluation of KPS score in the treatment group was better than that in the control group (P 0.05). 4. There was no significant difference in body weight between the two groups before and after treatment (P 0.05), but it in the control group was lower than that before treatment (P 0.05). There was no significant difference in blood system, renal function and neurotoxicity between the two groups after treatment (P 0.05), but the number of nausea and vomiting and diarrhea in the treatment group was less than that in the control group (P 0.05). Conclusion: Xu's Shenqi Yizhu decoction combined with chemotherapy can improve the symptoms of stomachache, epigastric distension, less food, pan-acid, loose stool, fatigue and so on, improve the functional condition of the body, reduce the adverse reactions such as nausea, vomiting and diarrhea caused by chemotherapy, and improve the quality of life of patients with gastric cancer after operation.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.2
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