核酸适配体在肿瘤靶向治疗中的研究进展
发布时间：2019-07-21 14:38
【摘要】：理想的肿瘤治疗制剂能特异性地靶向于肿瘤细胞,起到安全有效的药物传递作用。核酸适配体非同寻常的分子识别能力使得其成为最具前景的生物靶向分子。笔者从结合方式、载体种类等方面,以有代表性的核酸适配体与靶向制剂结合文献资料为依据,进行归纳、总结,综述了近5年来核酸适配体用于靶向肿瘤制剂构建的最新研究进展,并对存在的问题进行了分析与展望。
[Abstract]:The ideal tumor therapeutic preparation can specifically target tumor cells and play a safe and effective role in drug delivery. The unusual molecular recognition ability of nucleic acid aptamers makes it the most promising biological target molecule. Based on the literature on the combination of representative nucleic acid aptamers and targeted preparations from the aspects of binding mode and carrier types, the latest research progress of nucleic acid aptamers used in the construction of targeted tumor preparations in recent 5 years was reviewed, and the existing problems were analyzed and prospected.
【作者单位】： 大连医科大学基础医学院;大连医科大学药学院;
【基金】：国家自然科学基金资助项目(81202484)
【分类号】：R730.5
[Abstract]:The ideal tumor therapeutic preparation can specifically target tumor cells and play a safe and effective role in drug delivery. The unusual molecular recognition ability of nucleic acid aptamers makes it the most promising biological target molecule. Based on the literature on the combination of representative nucleic acid aptamers and targeted preparations from the aspects of binding mode and carrier types, the latest research progress of nucleic acid aptamers used in the construction of targeted tumor preparations in recent 5 years was reviewed, and the existing problems were analyzed and prospected.
【作者单位】： 大连医科大学基础医学院;大连医科大学药学院;
【基金】：国家自然科学基金资助项目(81202484)
【分类号】：R730.5
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