氨磷汀预防化疗致周围神经毒性疗效与安全性的系统评价
发布时间：2019-07-21 19:23
【摘要】：目的:系统评价氨磷汀预防化疗致周围神经毒性(CIPN)的疗效和安全性,为临床提供循证参考。方法:计算机检索PubMed、EMBase、Cochrane图书馆、相关期刊论文、万方数据库和中文科技期刊数据库,收集氨磷汀联合化疗(试验组)对比单纯化疗(对照组)用于肿瘤患者的随机对照试验(RCT),资料提取并采用改良的Jadad评分量表评价质量后,采用RevMan 5.3统计软件进行Meta分析。结果:共纳入20项RCT,合计1 552例患者。Meta分析结果显示,试验组患者CIPN总发生率[RR=0.57,95%CI(0.45,0.72),P0.001]、严重CIPN发生率[RR=0.47,95%CI(0.32,0.69),P0.001]显著低于对照组,恶心发生率[RR=1.31,95%CI(1.03,1.67),P=0.03]、呕吐发生率[RR=2.28,95%CI(1.14,4.54),P=0.02]及低血压发生率[RR=28.29,95%CI(10.53,76.04),P0.001]显著高于对照组,差异均有统计学意义;两组患者客观缓解率比较,差异无统计学意义[RR=1.08,95%CI(0.98,1.19),P=0.14]。结论:氨磷汀能有效预防肿瘤患者化疗致CIPN的发生,且不影响化疗疗效,但会加重患者化疗后恶心、呕吐的发生,并易诱发低血压。
[Abstract]:Objective: to systematically evaluate the efficacy and safety of amifostine in the prevention of peripheral neurotoxicity (CIPN) induced by chemotherapy, and to provide evidence-based reference for clinical practice. Methods: the PubMed,EMBase,Cochrane Library, Chinese Journal full-text Database, Wanfang Database and Chinese Sci-tech Journal Database were searched by computer. The (RCT), data of patients with tumor were collected and compared with chemotherapy alone (control group). The quality of (RCT), was evaluated by improved Jadad scale. Meta analysis was carried out by RevMan 5.3 statistical software. Results: a total of 1552 patients with 20 items of RCT, were included. Meta-analysis showed that the total incidence of CIPN [RR=0.57,95%CI (0.45,0.72), P0.001], the incidence of severe CIPN [RR=0.47,95%CI (0.32, 0.69), P0.001] were significantly lower than those in the control group, the incidence of nausea [RR=1.31,95%CI (1.03, 1.67), P 鈮，
本文编号：2517367
[Abstract]:Objective: to systematically evaluate the efficacy and safety of amifostine in the prevention of peripheral neurotoxicity (CIPN) induced by chemotherapy, and to provide evidence-based reference for clinical practice. Methods: the PubMed,EMBase,Cochrane Library, Chinese Journal full-text Database, Wanfang Database and Chinese Sci-tech Journal Database were searched by computer. The (RCT), data of patients with tumor were collected and compared with chemotherapy alone (control group). The quality of (RCT), was evaluated by improved Jadad scale. Meta analysis was carried out by RevMan 5.3 statistical software. Results: a total of 1552 patients with 20 items of RCT, were included. Meta-analysis showed that the total incidence of CIPN [RR=0.57,95%CI (0.45,0.72), P0.001], the incidence of severe CIPN [RR=0.47,95%CI (0.32, 0.69), P0.001] were significantly lower than those in the control group, the incidence of nausea [RR=1.31,95%CI (1.03, 1.67), P 鈮，
本文编号：2517367
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