膳食大豆食物摄入与全肿瘤死亡风险关系的前瞻性队列研究

发布时间：2019-08-12 15:56

【摘要】：目的:探讨膳食大豆食物摄入与全肿瘤死亡风险的关系。方法:利用上海男性健康队列(2002—2013年)和上海女性健康队列(1997—2013年)的调查资料,采用食物频率调查表收集膳食大豆食物摄入的相关信息。使用COX比例风险模型调整潜在混杂因素,估算膳食大豆食物摄入与全肿瘤死亡的风险比(hazard ratio,HR)及其95%可信区间(95%confidence interval,95%CI)。结果:最终纳入59 857名男性和73 044名女性参与者。上海男性和女性健康队列分别平均随访9.2年和14.7年,确诊2 122例男性和2 580例女性恶性肿瘤死亡病例。以膳食大豆食物摄入量最低四分位组为参考,男女性最高摄入组人群的HR分别为0.99(95%CI:0.87~1.12)和0.96(95%CI:0.85~1.08),提示膳食大豆食物摄入与全肿瘤死亡风险的关联没有统计学意义。进一步的分析结果提示,膳食大豆异黄酮摄入水平与男女性全肿瘤死亡风险也没有关联,相应的HR分别为1.06(95%CI:0.93~1.19)和0.98(95%CI:0.88~1.10)。结论:膳食大豆食物摄入可能与全肿瘤死亡风险的降低没有关联。
[Abstract]:Objective: To study the relationship between dietary soybean food intake and the risk of total tumor death. Methods: Using the survey data of Shanghai Male Health Cohort (2002-2013) and Shanghai Women's Health Cohort (1997-2013), the information about the intake of dietary soybean food was collected using the food frequency questionnaire. The potential confounding factors were adjusted using the COX proportional risk model to estimate the risk ratio (hazard ratio, HR) and 95% confidence interval (95% confidence interval,95% CI) for dietary soybean food intake and total tumor death. Results:59 857 men and 73 044 female participants were included. The average follow-up of the Shanghai male and female health cohort was 9.2 years and 14.7 years, and 2122 male and 2,580 cases of female malignant tumor were diagnosed. The HR of the highest intake group was 0.99 (95% CI: 0.87-1.12) and 0.96 (95% CI: 0.85-1.08), suggesting that the association between dietary soybean food intake and the risk of total tumor death was not statistically significant. The results suggested that the dietary soybean isoflavone intake was not associated with the risk of the death of the male and female, and the corresponding HR was 1.06 (95% CI: 0.93-1.19) and 0.98 (95% CI: 0.88-1.10). Conclusion: The food intake of dietary soybean may not be associated with the reduction of the risk of total tumor death.
【作者单位】：复旦大学公共卫生学院;上海交通大学医学院附属仁济医院上海市肿瘤研究所癌基因及相关基因国家重点实验室和流行病学研究室;美国范德堡大学医学中心流行病学中心;
【基金】：国家重点研发计划重大慢性非传染疾病防控研究专项(编号:2016YFC1302503) 癌基因及相关基因国家重点实验室自主研究项目(编号:91-15-10) 美国国家卫生署项目(编号:UM1CA182910,UM1CA173640)~~
【分类号】：R730.1

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