食管鳞癌患者Periostin和EGFR的表达及预后意义
发布时间：2021-02-08 23:43
背景和目的食管鳞癌（Esophageal squamous cell carcinoma,ESCC）具有起病隐匿、很难在早期被发现和诊断的特点。虽然用于诊断和治疗ESCC的方法与时俱进,但是ESCC患者预后并不理想。因此寻找有效的分子生物标志物,用于监测食管鳞癌患者的疾病进展及生存时间显得尤为迫切和必要。骨膜蛋白（Periostin,PO）和表皮生长因子受体（Epidermal growth factor receptor,EGFR）广泛表达于恶性实体肿瘤中。PO,作为胞外基质蛋白,与整合素结合后向胞内传递信息,在促进肿瘤细胞增殖,诱导肿瘤新生血管形成和化疗耐药等方面扮演了重要角色。细胞表面的EGFR和胞外基质中的PO有无关系及它们共同表达对ESCC患者的预后有无影响尚不明确。本实验旨在探讨PO和EGFR在ESCC患者中的表达及相关性,同时分析PO和EGFR的表达水平对ESCC患者生存时间的影响,判断其作为今后食管鳞癌靶向治疗的潜在临床价值。方法收集83例ESCC患者癌及癌旁正常组织标本,应用免疫组化方法检测PO和EGFR的表达。EGFR和PO蛋白表达水平与临床病理特征之间的关系采用卡...
【文章来源】：安徽医科大学安徽省
【文章页数】：55 页
【学位级别】：硕士
【部分图文】：
PO和EGFR在食管鳞癌组织中免疫组化图
图 2 食管鳞癌与癌旁 PO 和 EGFR 蛋白的 IHC 评分图es of PO and EGFR expression in ESCC and tumor-adjace形图代表癌组织蛋白表达，白色条形图代表癌旁正常组ns expressed in ESCC tumors (black bar graph) and proteitumor-adjacent normal tissues (white bar graph). 与临床病理特征的关系 PO 蛋白的表达以 IHC 评分≥4 分和＜4 分，分别 高表达与 ESCC 的肿瘤大小（P = 0.044）、浸润.010）、肿瘤分期（P = 0.000）和淋巴结转移分化、年龄和性别无关（表 1）。
O 和 EGFR 高表达与低表达食管鳞癌患者的 Kaplan-Meier 生存曲线图–Meier survival curves in ESCC patients according to the high or low exprePO and EGFRA PO 高表达组患者的 DFS 较低表达组明显降低ts in PO-high expression group had a significantly lower DFS than those inexpression group.B PO 低表达组患者的 OS 较高表达组明显延长nts in PO-low expression group had a significantly better OS than those in expression group.C EGFR 高表达组患者的 DFS 较低表达组明显缩短ients in EGFR-high expression group had a significantly worse DFS than thEGFR-low expression group.D EGFR 低表达组患者的 OS 较高表达组明显增高
【参考文献】：
期刊论文
[1]Annual report on status of cancer in China, 2011[J]. Wanqing Chen,Rongshou Zheng,Hongmei Zeng,Siwei Zhang,Jie He. Chinese Journal of Cancer Research. 2015(01)
[2]食管鳞状细胞癌组织中Periostin、VEGF的表达及意义[J]. 李超,徐小玲,王玲,秦珊,朱于启. 临床与实验病理学杂志. 2014(12)
[3]食管癌血管生成的研究进展[J]. 王伟,胡冰,何义富. 国际肿瘤学杂志. 2014 (01)
[4]Correlation between periostin and SNCG and esophageal cancer invasion,infiltration and apoptosis[J]. Jin-Hong Luo,Jun Zhou,Yong Gao. Asian Pacific Journal of Tropical Medicine. 2013(07)
[5]子宫内膜腺癌患者血浆CA125、Periostin水平变化及意义[J]. 陈政,林飞峰. 山东医药. 2013(04)
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[8]Expression of periostin and its clinicopathological relevance in gastric cancer[J]. Jun-Sheng Li, Guang-Wen Sun, Wen-Hao Tang, Department of General Surgery, Affiliated Zhong-Da Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China Xiao-Ying Wei, Department of Pathology, Affiliated Zhong-Da Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China. World Journal of Gastroenterology. 2007(39)
博士论文
[1]鼻咽癌间质的定量蛋白质组学研究[D]. 李美香.中南大学 2009
本文编号：3024686
【文章来源】：安徽医科大学安徽省
【文章页数】：55 页
【学位级别】：硕士
【部分图文】：
PO和EGFR在食管鳞癌组织中免疫组化图
图 2 食管鳞癌与癌旁 PO 和 EGFR 蛋白的 IHC 评分图es of PO and EGFR expression in ESCC and tumor-adjace形图代表癌组织蛋白表达，白色条形图代表癌旁正常组ns expressed in ESCC tumors (black bar graph) and proteitumor-adjacent normal tissues (white bar graph). 与临床病理特征的关系 PO 蛋白的表达以 IHC 评分≥4 分和＜4 分，分别 高表达与 ESCC 的肿瘤大小（P = 0.044）、浸润.010）、肿瘤分期（P = 0.000）和淋巴结转移分化、年龄和性别无关（表 1）。
O 和 EGFR 高表达与低表达食管鳞癌患者的 Kaplan-Meier 生存曲线图–Meier survival curves in ESCC patients according to the high or low exprePO and EGFRA PO 高表达组患者的 DFS 较低表达组明显降低ts in PO-high expression group had a significantly lower DFS than those inexpression group.B PO 低表达组患者的 OS 较高表达组明显延长nts in PO-low expression group had a significantly better OS than those in expression group.C EGFR 高表达组患者的 DFS 较低表达组明显缩短ients in EGFR-high expression group had a significantly worse DFS than thEGFR-low expression group.D EGFR 低表达组患者的 OS 较高表达组明显增高
【参考文献】：
期刊论文
[1]Annual report on status of cancer in China, 2011[J]. Wanqing Chen,Rongshou Zheng,Hongmei Zeng,Siwei Zhang,Jie He. Chinese Journal of Cancer Research. 2015(01)
[2]食管鳞状细胞癌组织中Periostin、VEGF的表达及意义[J]. 李超,徐小玲,王玲,秦珊,朱于启. 临床与实验病理学杂志. 2014(12)
[3]食管癌血管生成的研究进展[J]. 王伟,胡冰,何义富. 国际肿瘤学杂志. 2014 (01)
[4]Correlation between periostin and SNCG and esophageal cancer invasion,infiltration and apoptosis[J]. Jin-Hong Luo,Jun Zhou,Yong Gao. Asian Pacific Journal of Tropical Medicine. 2013(07)
[5]子宫内膜腺癌患者血浆CA125、Periostin水平变化及意义[J]. 陈政,林飞峰. 山东医药. 2013(04)
[6]中国食管癌流行病学现状、诊疗现状及未来对策[J]. 赫捷,邵康. 中国癌症杂志. 2011(07)
[7]Enhanced proliferation,invasion,and epithelial-mesenchymal transition of nicotine-promoted gastric cancer by periostin[J]. Yu Liu,Bao-An Liu,Division of Basic Medicine,Department of Pathology,Central South University Xiangya School of Medicine,Changsha 410 013,Hunan Province,China. World Journal of Gastroenterology. 2011(21)
[8]Expression of periostin and its clinicopathological relevance in gastric cancer[J]. Jun-Sheng Li, Guang-Wen Sun, Wen-Hao Tang, Department of General Surgery, Affiliated Zhong-Da Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China Xiao-Ying Wei, Department of Pathology, Affiliated Zhong-Da Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China. World Journal of Gastroenterology. 2007(39)
博士论文
[1]鼻咽癌间质的定量蛋白质组学研究[D]. 李美香.中南大学 2009
本文编号：3024686
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