揿针联合氯雷他定治疗儿童持续性过敏性鼻炎的临床研究

发布时间：2017-12-27 18:33

本文关键词：揿针联合氯雷他定治疗儿童持续性过敏性鼻炎的临床研究　出处：《成都中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：运用揿针联合氯雷他定治疗儿童持续性过敏性鼻炎(Persistent Allergic Rhinitis,PAR),观察评估揿针联合氯雷他定治疗儿童PAR的有效性和安全性。方法：将75例PAR合格受试者,按2：2：1随机分成三组：治疗组(揿针加药物组)30例,对照组Ⅰ(揿针组)30例,对照组Ⅱ(假针加药物组)15例。治疗组取印堂、双迎香、双足三里和双肺俞,将揿针贴于上述穴位,一周两次；并按患者年龄及体重服用相应剂量的氯雷他定片,每日一次,共服用三周。对照组Ⅰ针刺选穴、操作同治疗组,不用药物。对照组Ⅱ针刺使用定制的无针芯假针,余同治疗组。治疗前后采用症状量化评分表、症状视觉模拟量表(VAS)及鼻结膜炎相关生活质量评分表(RQLQ)进行评估,观察外周血清嗜酸性粒细胞百分比(EOSR)变化情况,于治疗结束3周后随访复发情况。结果：(1)疗效比较：治疗后,治疗组总有效率92.31%,对照组Ⅰ总有效率90.00%,对照组Ⅱ总有效率71.43%；治疗组与对照组Ⅰ比较差异无统计学意义(P0.05),与对照组Ⅱ比较差异有统计学意义(P0.05)。(2)症状与生活质量改善比较：组内比较：三组治疗前后的症状量化评分、VAS评分及RQLQ评分组内比较,差异均有统计学意义(P0.05)；组间比较：治疗后,在改善症状量化评分和RQLQ评分方面,治疗组优于对照组Ⅱ(P0.05),与对照组Ⅰ比较差异无统计学意义(P0.05)；治疗后,治疗组与两个对照组的VAS评分差异均无统计学意义(P0.05)。(3)外周血清EOSR比较：三组治疗前后的外周血清EOSR组内比较差异有统计学意义(P0.05)；治疗后,治疗组与两个对照组组间比较差异无统计学意义(P0.05)。(4)复发率比较：治疗结束3周后进行随访,治疗组与两个对照组组间复发率比较,差异均无统计学意义(P0.05)。结论：(1)揿针加氯雷他定、揿针治疗儿童PAR安全、有效。(2)揿针加药物组在疗效、降低症状量化评分及改善生活质量方面优于假针加药物组。(3)揿针加药物组与揿针组和假针加药物组在缓解患者症状主观感受、降低外周血EOSR和防止病情复发方面无显著性差异。
[Abstract]:Objective: to use the needle combined with loratadine in treatment of children with persistent allergic rhinitis (Persistent Allergic, Rhinitis, PAR), to evaluate the efficacy and safety of needle combined with loratadine in the treatment of children with PAR. Methods: 75 cases of PAR qualified subjects, divided into three groups randomly: treatment group (by 2:2:1 needle plus drug group) 30 cases, control group I (needle group) 30 cases, control group II (sham acupuncture plus medication group of 15 cases). The treatment group, Yintang, double li20, double double Zusanli and Feishu, will press needle affixed to the above points, two times a week; and taking the corresponding dose of Loratadine Tablets according to the age and weight of patients, once a day, taking a total of three weeks. The control group I selected acupuncture points and operated the same treatment group without drugs. In the control group, the needling needle without needle core was used in the control group, and the treatment group was the same as the treatment group. Before and after treatment, symptom Quantification Scale, symptom visual analogue scale (VAS) and nasal conjunctivitis related quality of life scale (RQLQ) were used to evaluate the changes of peripheral blood eosinophil percentage (EOSR). After 3 weeks of treatment, the recurrence rate was observed. Results: (1) curative effect comparison: after treatment, the total effective rate of the treatment group was 92.31%, the total effective rate of the control group was 90%, the total effective rate of the control group was 71.43%, the difference between the treatment group and the control group was not statistically significant (P0.05), and the difference between the treatment group and the control group was statistically significant (P0.05). (2) comparison of symptoms and quality of life: group comparison: three groups before and after treatment of the symptom score and VAS score and RQLQ score in comparison, the differences were statistically significant (P0.05); group comparison: after treatment, in improving symptoms score and RQLQ score, the treatment group than the control group (II P0.05), and the control group had no significant difference (P0.05); after treatment, VAS score between the treatment group and two in the control group had no statistical significance (P0.05). (3) peripheral serum EOSR: there was a significant difference between the three groups before and after treatment in the EOSR group (P0.05). After treatment, there was no significant difference between the treatment group and the two control groups (P0.05). (4) the recurrence rate was compared: after 3 weeks of treatment, the recurrence rate was compared between the treatment group and the two control groups, the difference was not statistically significant (P0.05). Conclusion: (1) the acupuncture plus loratadine, needle is safe and effective in treatment of children with PAR. (2) the acupuncture plus medication group reduced symptoms score and improve the quality of life is better than sham acupuncture plus medication group in curative effect. (3) the acupuncture plus drug group and the acupuncture group and sham acupuncture plus medication group in relieving the symptoms of subjective feeling, reduce the peripheral blood EOSR and prevent the recurrence of the disease had no significant difference.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R276.1

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