祛湿通络丸治疗强直性脊柱炎的疗效及其对MMP-3的影响

发布时间：2017-12-28 01:10

  本文关键词：祛湿通络丸治疗强直性脊柱炎的疗效及其对MMP-3的影响　出处：《黑龙江省中医药科学院》2016年硕士论文　论文类型：学位论文

  更多相关文章： 强直性脊柱炎 寒湿痹阻型 祛湿通络丸 临床研究

【摘要】：目的:观察祛湿通络丸对寒湿痹阻型强直性脊柱炎患者ASAS疗效、BASMI评测指标的影响,观察患者主次症、晨僵时间、最大踝间距等改善情况,病理学研究方面对比治疗前后MMP-3等指标水平,从而综合论证祛湿通络丸治疗强直性脊柱炎的疗效,探讨祛湿通络丸可能作用机制;并检测祛湿通络丸对血尿常规、肝肾功能等的影响来评价其安全性。方法:将65例符合标准的强直性脊柱炎患者随机分为治疗组和对照组,其中脱落12例,脱落后治疗组28例,对照组25例,疗程12周,观察点分别为治疗前、治疗后。两组均在口服非甾体抗炎药(洛索洛芬钠片,60mg,tid)的同时,治疗组口服祛湿通络丸,6g,tid;对照组口服正清风痛宁缓释片,120mg,tid,作相应记录,观察患者主症、次症、晨僵时间、最大踝间距等改善情况,监测ASAS、BASMI等药物疗效评定指标,观察对比治疗前、后MMP-3等指标水平,监测记录药物的不良反应。结果:实验组和对照组在改善患者中医临床相关主要症候,提高患者生活质量,降低ASAS、BASMI各项主要指标,缓解MMP-3、ESR、CRP等实验室指标方面与治疗前相比有显著差异(P0.05),治疗组总有效率达71.4%,对照组总有效率60.0%,治疗组优于对照组。结论:祛湿通络丸治疗寒湿痹阻型强直性脊柱炎能够有效改善患者主要症状、体征及MMP-3、CRP、ESR等指标,安全有效。
[Abstract]:Objective: To observe the effect of Qushi Tongluo Pill on cold dampness blockage type ASAS in patients with ankylosing spondylitis curative effect, BASMI evaluation index, observed in patients with primary and secondary disease, time of morning stiffness, maximum ankle spacing improvement, pathology study compared before and after treatment MMP-3 levels, the effect to the comprehensive demonstration of Qushi Tongluo pill in the treatment of ankylosing spondylitis. To explore the possible mechanism of Qushi Tongluo pill; and to detect the influence of qushitongluo Pill on blood and urine routine, liver and kidney function to evaluate its safety. Methods: 65 cases of ankylosing spondylitis conforming to the standard were randomly divided into treatment group and control group, including 12 cases of abscission, 28 cases of treatment group and 25 cases of control group. The treatment course was 12 weeks, the observation points were before treatment and after treatment. In two groups of oral non steroidal anti-inflammatory drugs (Loxoprofen Sodium Tablets, 60mg, TID) at the same time, the treatment group oral qushitongluo pill, 6G, TID; the control group oral Zhengqingfengtongning sustained-release tablets, 120mg, TID, the corresponding record, observe the main symptoms and secondary symptoms of patients, the time of morning stiffness, maximum ankle spacing to improve the situation, evaluation index ASAS and BASMI monitoring the efficacy of drugs, were compared before and after treatment, MMP-3 index level, the drug adverse reaction monitoring records. Results: the experimental group and the control group in improving TCM related clinical syndrome, improve the quality of life of patients, reduce the main index of BASMI ASAS, MMP-3, ESR, CRP, alleviate the laboratory indicators compared with before treatment there were significant differences (P0.05), the total efficiency of treatment group was 71.4%, control group total effective rate was 60%, the treatment group than the control group. Conclusion: qushitongluo pill in the treatment of cold dampness type of ankylosing spondylitis can effectively improve the clinical symptoms, signs and MMP-3, CRP, ESR and other indicators, safe and effective.
【学位授予单位】：黑龙江省中医药科学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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本文编号：1343945