参芪六味汤对脾虚痰湿型冠心病稳定型心绞痛临床疗效研究

发布时间：2017-12-28 06:35

本文关键词：参芪六味汤对脾虚痰湿型冠心病稳定型心绞痛临床疗效研究　出处：《广西中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本研究旨在通过观察参芪六味汤对脾虚痰湿型冠心病稳定型心绞痛的中医症候、心电图、硝酸甘油用量、心绞痛症状及C-反应蛋白的变化和影响,进而探究其临床疗效。方法:在2015年2月至2015年12月长春中医药大学附属医院心病二科住院部及门诊,选择符合纳入标准的稳定型心绞痛患者60例,中医辨证为脾虚痰湿证,用简单随机法中的掷骰子法分为治疗组与对照组。比例为1:1,即每组30例。治疗组给予基础西药加用参芪六味汤治疗,其中基础西药治疗包括(可根据临床实际情况调整用药):阿司匹林肠溶片100mg/日,酒石酸美托洛尔片100mg/日,阿托伐他汀钙片20mg/日;对照组给予基础西药治疗。临床观察共为期4周。观察治疗组和用药组病例用药前后的临床症状,记录中医症候评分、硝酸甘油的服用量、心电图、心绞痛症状以及C-反应蛋白,记录并分析前后数据的变化。结果:1、参芪六味汤能明显降低脾虚痰湿型冠心病稳定型心绞痛患者的中医症候积分,对心绞痛的症状有明显的改善;2、通过对比发现,参芪六味汤与基础西药联合使用可以改善冠心病稳定型心绞痛患者的心电图;3、通过临床观察,参芪六味汤与基础西药联合使用可以有效减少冠心病稳定型心绞痛患者硝酸甘油用量;4、通过对比观察,参芪六味汤可改善冠心病稳定型心绞痛患者的心绞痛症状。5、通过临床试验观察,未发现患者服用参芪六味汤后有不良反应发生。结论:参芪六味汤能改善冠心病稳定型心绞痛患者的临床症状,改善心电图心肌缺血情况,减少硝酸甘油的服用量,疗效安全、确切,值得临床推广,未来有广泛的前景。
[Abstract]:Objective: To observe the clinical efficacy of Shenqi six flavor Decoction on TCM syndrome, electrocardiogram, nitroglycerin consumption, angina pectoris symptoms and C- reactive protein in patients with stable angina pectoris due to spleen deficiency and phlegm dampness type. Methods: from February 2015 to December 2015 in the heart of Affiliated Hospital of Changchun University of Traditional Chinese Medicine two Department of inpatient and outpatient, with a total of 60 patients with stable angina pectoris standard, TCM syndrome of the spleen with phlegm, using dice method simple random method were divided into treatment group and control group. The proportion was 1:1, that is, 30 cases in each group. The treatment group was given Shenqi decoction plus Western medicine treatment six, which is the basis of Western medicine treatment (including medication can be adjusted according to the clinical conditions): Aspirin Enteric-coated Tablets 100mg/, Metoprolol Tartrate Tablets 100mg/, Atorvastatin Calcium Tablets 20mg/; the control group was given the basic treatment of Western medicine. The clinical observation lasted for 4 weeks. Observe the clinical symptoms before and after treatment in the treatment group and the medication group, record the TCM symptom score, the dosage of nitroglycerin, the electrocardiogram, angina pectoris symptoms and C- reactive protein, record and analyze the changes of the data before and after treatment. Results: 1, six Shenqi decoction can significantly reduce the TCM symptoms of spleen deficiency type patients with stable angina pectoris of coronary heart disease, the angina symptoms were obviously improved; 2, by comparison, combined with Shenqi decoction and Western medicine six can improve electrocardiogram in patients with stable angina pectoris of coronary heart disease; 3, through clinical observation, combined with Shenqi decoction and Western medicine six can effectively reduce the stable angina pectoris of coronary heart disease patients with the dosage of nitroglycerin; 4, by comparison, six Shenqi decoction can improve the patients with stable angina pectoris of coronary heart disease angina pectoris. 5, through clinical trial observation, no patients were found to take Shenqi six flavour soup after the adverse reaction. Conclusion: Shenqi six flavor decoction can improve the clinical symptoms of coronary heart disease patients with stable angina pectoris, improve the myocardial ischemia and reduce the dosage of nitroglycerin, which is safe and accurate. It is worthy of clinical promotion and has wide prospects in the future.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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