原发性干燥综合征300例的用药规律研究

发布时间：2017-12-28 12:32

本文关键词：原发性干燥综合征300例的用药规律研究　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过对李泽光教授治疗原发性干燥综合征(Primary Sjogren's sy ndrome,pSS)的病案收集、方药整理以及用药数据分析,总结出李泽光教授治疗原发性干燥综合征的用药规律及学术思想。方法:整理2015年-2017年李泽光教授治疗原发性干燥综合征门诊初诊病案300例,将其方药采用频数分析、聚类分析、因子分析等方法进行归纳与分析。结果:1.频数分析结果:300则处方用药共197味,总使用频次为6347次。其中使用频数前46味的中药,频数均在30次以上,累积频率达80.40%,是治疗原发性干燥综合征的主要药物,使用频数前20味的中药,频数均在100次以上,累计频率达60.49%,是治疗原发性干燥综合征的核心药物;四气统计中,寒性药使用频率最高,微寒性次之,其次为平性和温性,热性与大寒性药物基本没有出现。五味统计中,甘味药物出现频率最高,苦味次之,其次为辛、酸、涩、咸、淡。归经统计中,以归肝、肺、胃经的药物频率最高。药物类别统计中,以清热药使用频率最高,其次分别是补虚药、活血化瘀药、祛风湿药、解表药、利水渗湿药。2.聚类分析结果:本研究对频数在30次以上,总使用频率80.40%以上的46味中药进行聚类分析,得出治疗原发性干燥综合征的常用药对8个,3味药组合5个及多味药物组合4个,多为导师针对原发性干燥综合征口干、眼干而设的滋阴润燥、清热解毒药对、药组,它们分别从不同角度体现了导师临证组方思维特点、组方原则等。3.因子分析结果:本研究对频数在30次以上,总使用频率80.40%以上的46味中药进行因子分析,得出公因子14个,从多个角度反映了原发性干燥综合征的内在病机及导师的治法治则等。结论:1.生地黄、秦皮、芦根、白芍、菊花、忍冬藤、金银花、麦冬、甘草、郁金、茯苓、乌梅、百合、北沙参、鸡血藤、合欢皮、延胡索、白术、威灵仙、陈皮是导师治疗原发性干燥综合征的核心药物。2.清热药、补虚药、活血化瘀药、解表药、祛风湿药是导师治疗原发性干燥综合征的基本组成类别。3.酸甘化阴、清热解毒、活血化瘀是导师治疗原发性干燥综合征最常用的用药法则。
[Abstract]:Objective: To summarize professor Li Zeguang's medication rules and academic thoughts in treating primary Sjogren's syndrome by collecting professor Li Zeguang's Primary Sjogren's sy ndrome (pSS), collecting prescription data and analyzing drug data. Methods: in 2015 -2017, 300 cases of primary Sjogren's syndrome in the outpatient clinic were treated in 2015. Results: 1. frequency analysis results: 300 prescriptions were 197 flavors, and the total use frequency was 6347 times. The use of traditional Chinese medicine 46 kinds of frequency, the frequency was more than 30 times, the cumulative frequency of 80.40%, is the main drug for the treatment of primary Sjogren syndrome, the use of traditional Chinese medicine 20 kinds of frequency, frequency of more than 100 times, the cumulative frequency of 60.49%, is the core of drug treatment of primary Sjogren syndrome statistics; four, the highest frequency of use of cold medicine, micro cold times, followed by flat and warm, hot and cold drugs does not appear. Five kinds of statistics, the highest frequency of bitter sweet medicine, the second, followed by spicy, sour and astringent and salty, pale. By statistics, in the liver, lung and stomach medicine highest frequency. In the statistics of drug categories, the use frequency of antipyretic drugs is the highest, followed by supplementing deficiency drugs, activating blood and removing blood stasis drugs, removing wind and wet drugs, solving table drugs, and leothing and wetting drugs. The results of this study: 2. clustering frequency in more than 30 times, more than 80.40% of the total frequency of use of 46 traditional Chinese medicines by cluster analysis, the commonly used drugs for the treatment of primary Sjogren syndrome in 8, 3 drug combinations of 5 drugs and combination of the 4, is designed for primary teachers dry dry dry mouth, dry eye syndrome, Ziyin Runzao, detoxification of drugs and drug group, they were from different angle reflects the characteristics of thinking, the teacher certificate prescription prescription principle etc.. 3. factor analysis results: in this study, we conducted factor analysis for 46 Chinese herbs with frequency above 30 times and 80.40% of total frequency, and got 14 common factors, which reflected the intrinsic pathogenesis of primary Sjogren syndrome and the governors' treatment principles from multiple perspectives. Conclusion: 1. radix rehmanniae, cortex Fraxini, reed rhizome, Radix Paeoniae Alba, chrysanthemum, honeysuckle, honeysuckle, licorice, ophiopogon root, turmeric, Poria, plum, lily, Glehnia root, Caulis Spatholobi, Albizzia julibrissin, Atractylodes, Rhizoma Corydalis, Radix Clematidis, tangerine peel is the core drug mentor treatment of primary Sjogren syndrome. The basic composition of the tutor's treatment of primary Sjogren syndrome is 2. antipyretic drugs, supplementing deficiency drugs, activating blood circulation and removing stasis medicine, resolving the table medicine and removing wind and damp medicine. 3. sour and sweet Yin, detoxification, blood stasis is the mentor treatment of primary Sjogren syndrome is the most commonly used drug law.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R249;R259

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