四草饮治疗肝阳上亢型眩晕的临床观察

发布时间：2017-12-28 14:25

本文关键词：四草饮治疗肝阳上亢型眩晕的临床观察　出处：《河北医科大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察四草饮治疗肝阳上亢型眩晕的临床疗效、眩晕残障程度评分及其复发情况,并与西比灵胶囊对照,探讨四草饮治疗眩晕的作用机制及其对患者生活质量方面的影响,用于指导临床,探索中医药在眩晕中的治疗作用及疗效。方法:将符合本课题纳入标准的肝阳上亢型眩晕患者80例,按随机分层原则分为治疗组和对照组,治疗组口服四草饮,对照组口服西比灵胶囊,两组疗程均为1月。观察患者的临床疗效、治疗前后中医症候积分、眩晕残障程度评分、经颅多普勒、血流变及复发情况等相关指标来进行疗效评定。结果:1.临床疗效的比较:治疗组总有效率为92.50%,对照组总有效率为85.00%,差异有统计学意义(P0.05)。2.治疗前后中医症候积分比较:结果显示治疗组与对照组治疗后中医症候积分与治疗前比较均有显著性差异,具有统计学意义(P0.01);组间比较,治疗组中医症候积分下降幅度大于对照组,差异有统计学意义(P0.05)。3.眩晕残障程度评分的变化:治疗组与对照组的眩晕残障程度评分较治疗前均有明显改善,比较均有统计学显著差异(P0.01),说明对照组与治疗组均能有效降低患者障碍评分;治疗后,治疗组评分水平较对照组降低明显,两者比较有统计学意义(P0.05),表明治疗组对于改善患者的生活质量疗效更佳。4.治疗前后经颅多普勒指标的比较:治疗组治疗前、后比较差异显著,有统计学意义(P0.05);对照组舒张期的RVA、BA治疗前、后比较,无统计学意义(P0.05),余项治疗前、后均有统计学意义(P0.05);治疗组与对照组对比除收缩期RVA外,均有显著性差异,有统计学意义(P0.05)。5.治疗前后血流变指标的比较:治疗组血液流变学中全血黏度切变率、全血低切还原粘度改变明显优于对照组,比较有统计学意义(P0.05);治疗组治疗后血浆粘度、全血高切还原粘度与对照组相比无明显差异(P0.05)。6.复发率比较:治疗组40例,复发2例,复发率为5%;对照组40例,复发5例,复发率为12.5%。差别有统计学意义(P0.05)。7.安全性观察,治疗组在临床观察期间未出现明显不良反应。结论:四草饮能明显改善肝阳上亢型眩晕的中医症候积分及眩晕残障程度评分、血流变及经颅多普勒等指标,可提高患者生活质量、降低复发率,尤其是针对肝阳上亢型眩晕有较好的临床疗效,可进一步扩大样本量进行临床观察。
[Abstract]:Objective: To observe the clinical curative effect of four grass drink, treatment of liver yang hyperactivity type of vertigo vertigo disability score and recurrence, and the control and explore the mechanism of flunarizine capsules, four Cao Yin in the treatment of vertigo and its influence on the quality of life of the patients, to guide the clinical, explore and curative effect in medical treatment effect on vertigo the. Methods: will meet the inclusion criteria of liver yang hyperactivity type of vertigo patients 80 cases, randomly divided into treatment group and control group. The treatment group was treated with four grass decoction, control group was treated with flunarizine capsules, two groups were treated for January. The clinical efficacy, TCM symptom score, vertigo and disability score, transcranial Doppler, Hemorrheology and recurrence were observed before and after treatment. Results: 1. the comparison of clinical efficacy: the total effective rate in the treatment group was 92.50%, the total effective rate of the control group was 85%, and the difference was statistically significant (P0.05). Comparison of TCM syndrome score of 2. before and after treatment: the results showed that the treatment group and control group after treatment of TCM syndrome score before treatment were significantly different, with statistical significance (P0.01); comparison between groups, the treatment group TCM syndrome score decreased than that of control group, the difference was statistically significant (P0.05). 3. changes of vertigo degree of disability score: the treatment group and the control group of vertigo disability score were significantly improved compared with before treatment, there were statistically significant differences (P0.01), description of the control group and the treatment group can effectively reduce disorder score; after treatment, group scores were lower than those in control group were compared with treatment. Statistical significance (P0.05), showed that the treatment group for improving the quality of life of patients with better curative effect. Transcranial Doppler indexes before and after treatment: 4. patients before and after treatment, the difference was statistically significant (P0.05); RVA, BA treatment control group diastolic before and after comparison, no statistically significant (P0.05), more than before and after treatment were statistically significant (P0.05); the treatment group compared with the control group except systolic RVA, significant difference was statistically significant (P0.05). Comparison of indexes of blood rheology of 5. before and after treatment: the treatment group in the blood rheology of whole blood viscosity, whole blood low shear rate viscosity change significantly better than the control group, there was statistically significant difference (P0.05); after treatment, plasma viscosity, whole blood reduction viscosity compared with the control group had no significant difference (P0.05). 6. the recurrence rate was compared: 40 cases in the treatment group, 2 cases recurred, the recurrence rate was 5%, 40 cases in the control group, 5 cases recurred, and the recurrence rate was 12.5%. The difference was statistically significant (P0.05). 7. safety observation, in the treatment group, there was no obvious adverse reaction during the clinical observation. Conclusion: four grass decoction can significantly improve the liver yang hyperactivity type of vertigo symptom scores and vertigo degree of disability score, hemorheology and transcranial Doppler indexes can improve the quality of life of patients, reduce the recurrence rate, especially for ganyangshangkang type vertigo has good clinical curative effect, can further expand the sample size for clinical observation.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R255.3

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