基于因子分析和聚类分析的220例慢性精神分裂症中医证候规律研究

发布时间：2017-12-30 20:00

本文关键词：基于因子分析和聚类分析的220例慢性精神分裂症中医证候规律研究　出处：《中华中医药杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的:研究和探讨慢性精神分裂症的中医证候特征和分型规律,为该病中医证候的客观化研究提供参考依据。方法:根据课题组制定的《精神分裂症中医证候信息采集表》,通过标准化四诊信息采集,共纳入符合西医慢性精神分裂症诊断标准的病例220例,建立数据库,采因子分析和聚类分析等多元数理统计学方法,进行中医证候研究。结果:基于因子分析和聚类分析的220例慢性精神分裂症病例中医证候研究共得到22个公因子,结合专业知识,经专家讨论后,合并为6个最为符合临床的因子证侯组合,按解释的总方差由高到低依次为气滞血瘀型(28.18%)、痰湿内阻型(25.90%)、心脾两虚型(24.55%)、火盛伤阴型(15.91%)、肝郁脾虚型(3.18%)、心肝火炽型(2.27%)。结论:因子分析和聚类分析等多元数理统计学方法可用于慢性精神分裂症中医证候客观化研究,从证候规律和病机特点来看,气滞、血瘀和痰湿为慢性精神分裂症的主要病理因素。
[Abstract]:Objective: To study and explore the characteristics of TCM Syndromes of chronic schizophrenia and typing rules and provide reference for the objective study of TCM Syndromes of this disease. Methods: according to the research group to develop "schizophrenia TCM syndrome information collection table >, by the standard of four diagnostic information collection, included with the western medicine of chronic the diagnostic criteria of schizophrenia patients in 220 cases, the establishment of database, mining factor analysis and cluster analysis of multivariate statistical method, for the research of TCM syndrome. Results: 220 cases of chronic spirit factor analysis and cluster analysis of schizophrenia case study on TCM syndromes were obtained based on 22 factors, combined with professional knowledge, by experts after the discussion, with the 6 most consistent with the clinical syndrome factor combination, according to the total variance explained from high to low is Qi stagnation and blood stasis type (28.18%), phlegm dampness (25.90%), deficiency of two (24.55%), fire Sheng Yin type (15.91%), liver and spleen deficiency (3.18%), (2.27%) on the heart and liver type. Conclusion: the factor analysis and cluster analysis of multivariate statistical method can be used for chronic schizophrenia objective research of TCM Syndromes of qi stagnation syndrome from the division, rules and characteristics of pathogenesis, pathological, blood stasis and phlegm wet for chronic schizophrenia.

【作者单位】：黑龙江中医药大学;黑龙江神志医院;
【基金】：国家自然科学基金项目(No.81373776,No.81473444)~~
【分类号】：R277.7
【正文快照】： 精神分裂症是当前威胁人类健康的一种严重精神疾病,表现为感知、思维、情感、行为等多个方面的障碍和精神活动不协调,严重影响了人民群众的身心健康,对社会造成极大的负担[1]。精神分裂症属于中医神志病学癫、狂病范畴,《难经》中有“重阴者癫”“重阳者狂”,临床辨证多以阴、

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