针刺治疗消化性溃疡疗效的系统评价和Meta分析

发布时间：2017-12-31 05:20

本文关键词：针刺治疗消化性溃疡疗效的系统评价和Meta分析　出处：《针刺研究》2017年03期 　论文类型：期刊论文

更多相关文章： 消化性溃疡 针刺 系统评价 Meta分析

【摘要】：目的:系统评价针刺治疗消化性溃疡的临床疗效。方法:计算机检索相关期刊论文、万方数据库、重庆维普中文科技期刊数据库、中国生物医学文献数据库网络版、PubMed和Cochrane Library,检索从建库(刊)到2016年9月发表的关于针刺治疗消化性溃疡的随机对照试验(RCT),对符合纳入标准的文献进行资料提取和质量评价,应用RevMan 5.3统计软件对纳入的文献进行Meta分析。结果:最终纳入16项RCT,合计1 570例消化性溃疡患者。Meta分析结果显示:(1)针刺与西药比较:在有效率、溃疡面积愈合率、幽门螺杆菌(HP)转阴率方面,差异无统计学意义(P0.05);在复发率方面,针刺组低于西药组,差异具有统计学意义[RR=0.35,95%CI(0.14,0.84),P0.05]。(2)针刺+西药与西药比较:在有效率、溃疡面积愈合率、复发率方面,差异均具有统计学意义[RR=1.20,95%CI(1.04,1.38),P=0.01;RR=1.29,95%CI(1.06,1.58),P=0.01;RR=0.27,95%CI(0.16,0.45),P0.00001]。证据等级分析结果显示,除针刺治疗的溃疡面积愈合率和针刺HP转阴率评为"低级"外,其余都被评为"极低级"。结论:针刺联合西药治疗消化性溃疡对照常规西药具有一定的优势,但该结论的证据质量等级不高,研究结论需谨慎对待,需要大样本、高质量的随机对照试验进行进一步的验证。
[Abstract]:Objective: to evaluate the clinical efficacy of acupuncture in the treatment of peptic ulcer. Methods: the full text database of Chinese periodicals, the database of Wanfang and the database of Chinese scientific and technological journals of Weipu in Chongqing were searched by computer. Chinese biomedical literature database, online version of PubMed and Cochrane Library. A randomized controlled trial on the treatment of peptic ulcer with acupuncture was published in September 2016 from the establishment of the database (Journal) to the RCTA. The data were extracted and the quality was evaluated according to the inclusion criteria. RevMan 5.3 statistical software was used to analyze the included literature by Meta. Results: 16 items of RCT were included. A meta-analysis of 1 570 patients with peptic ulcer showed that compared with western medicine, the effective rate, healing rate of ulcer area and HP- negative rate of Helicobacter pylori were compared. The difference was not statistically significant (P 0.05). The recurrence rate of acupuncture group was lower than that of western medicine group, and the difference was statistically significant. [Compared with western medicine, acupuncture: effective rate, ulcer area healing rate, recurrence rate. The difference was statistically significant. [RRX 1.20 ~ 95% ~ 1.04 ~ 1.38 ~ 1. 01; RRX 1.29 and 95% CI1. 06 + 1. 58% P0. 01; RRX 0.27 / 95 CIQ 0.16 / 0.45 / P0.00001. Analysis of evidence levels shows. Except for the healing rate of ulcer area treated by acupuncture and the conversion rate of HP from acupuncture to negative, it was rated as "low grade". Conclusion: acupuncture combined with western medicine has certain advantages in the treatment of peptic ulcer, but the quality of evidence of this conclusion is not high, the conclusion should be treated with caution. Large sample, high-quality randomized controlled trials are needed for further validation.
【作者单位】：北京中医药大学针灸推拿学院;北京京北职业技术学院;首都医科大学附属北京朝阳医院中医科;
【分类号】：R246.1
【正文快照】： 消化性溃疡主要包括胃溃疡和十二指肠溃疡,是一种常见的消化系统疾病,在我国的发病率约为10%[1]。因具有病因复杂、病程长、自然缓解及反复发作的特点,给患者带来躯体、精神、经济上的多重损害。较为公认的消化性溃疡的发病机制为幽门螺杆菌(HP)感染,胃酸及胃蛋白酶等损伤因子

【相似文献】