基于Meta分析的中医利胆排石法治疗胆结石的系统评价

发布时间：2017-12-31 11:36

本文关键词：基于Meta分析的中医利胆排石法治疗胆结石的系统评价　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:分析研究利胆排石法治疗胆结石(gall-stone)的疗效及安全性,以系统评价该法治疗胆结石的优势,为中医药治疗胆结石提供循证医学的依据。方法:搜集1996.01-2015.12国内公开发表的关于利胆排石法治疗胆结石的研究文献,通过纳入及排除标准对文献进行严格筛选,以中医利胆排石法治疗为试验组,西药治疗为对照组,提取详细的相关信息并进行质量评价。采用Review Manager5.3软件Meta分析,对综合疗效、不良反应及化验指标变化情况等方面进行统计,制作森林图、研究敏感性及发表偏倚。结果:1.纳入30篇国内研究文献,共涉及3478例患者;2.研究文献的方法学质量评价整体略低,其中1分的2篇,2分的28篇,3-7分无;3.统计试验组的中药使用频率,以利胆排石药(金钱草、郁金、大黄、柴胡、白芍、鸡内金、枳壳、茵陈、蒲公英、甘草等)为主;4.Meta分析结果:中医利胆排石法治疗胆结石在综合疗效、减少不良反应及化验指标变化等方面与西药治疗相比,具有明显优势(P0.05)。结论:本研究表明,在胆结石的药物治疗方面,中医利胆排石法较西药治疗有明显优势,并阐述了近20年中医利胆排石法治疗胆结石的状况。不过,本研究的纳入文献质量普遍不高,故易导致发表偏倚的存在,望今后予以高质量、大样本的临床试验证实结果的可靠性,为中医药的稳定发展提供良好的实践支持。
[Abstract]:Objective: To study the Lidanpaishi treatment of gallstones (gall-stone) of the efficacy and safety of the system, to evaluate the treatment of gallstones, provide evidence-based basis for Chinese medicine treatment of gallstones. Methods: to collect literature 1996.01-2015.12 published Guan Yuli gall stone removing gallstones, through inclusion and exclusion the standard strict screening of the literature on TCM Lidanpaishi therapy as experimental group, western medicine control group, extract the relevant information in detail and quality evaluation. Using Review Manager5.3 analysis software Meta, the comprehensive efficacy, adverse reactions and laboratory index changes and other aspects of statistics, making forest map, sensitivity and research publication bias. Results: 1. into 30 domestic research literature, involving a total of 3478 patients; 2. methods of literature quality evaluation overall slightly lower, 1 of the 2 Article 2, 28, 3-7; 3. Chinese statistical test group used, lithggogue medicine with Lidan (Lysimachia, rhubarb, turmeric, Radix Paeoniae Alba, Radix Bupleuri, Gallus gallus, Fructus aurantii, wormwood, dandelion, licorice); 4.Meta analysis results: TCM Lidanpaishi treatment of gallstones in the comprehensive curative effect, compared to reduce adverse reactions and the change of laboratory indexes and other aspects of Western medicine, has the obvious advantage (P0.05). Conclusion: This study showed that in the drug treatment of gallstones, TCM Lidanpaishi method has obvious advantages compared with western medicine, traditional Chinese medicine in recent 20 years and describes the Lidanpaishi method in the treatment of gallstones. However, the research literature of the quality is not high, so it is easy to lead to the presence of publication bias, and we look forward to the high quality and reliability of clinical trials confirmed the results of a large sample, provided good practice for support for the steady development of Chinese medicine.

【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【相似文献】