自拟健脾助运汤治疗脾虚湿蕴型溃疡性结肠炎疗效观察

发布时间：2017-12-31 22:03

  本文关键词：自拟健脾助运汤治疗脾虚湿蕴型溃疡性结肠炎疗效观察　出处：《辽宁中医药大学》2016年硕士论文　论文类型：学位论文

  更多相关文章： 溃疡性结肠炎 脾虚湿蕴型 临床疗效

【摘要】：目的:以健脾祛湿,调理气血为治则,给予脾虚湿蕴型的UC患者自拟方剂健脾助运汤,联合美沙拉嗪缓释颗粒剂口服,观察对脾虚湿蕴型溃疡性结肠炎的临床治疗效果,通过对比患者肠黏膜、临床症状和体征及C反应蛋白治疗前后的变化,为溃疡性结肠炎的中西医结合治疗提供临床研究的依据。方法:选择符合纳入标准的患者44例,均来自2014年1月至2015年12月期间于辽宁中医药大学附属医院脾胃科住院部的患者。采用随机数字表法将患者随机分为治疗组和对照组2个组别,每组患者均为22例。给予两组患者相同基础治疗的同时,对照组予美沙拉嗪缓释颗粒剂1.0g,日3次口服;治疗组在对照组基础上另予自拟方药健脾助运汤100ml,日3次口服,两组患者疗程均为8周。对治疗前后2组患者临床症状积分、肠镜黏膜愈合情况及C反应蛋白变化进行比较。数据用SPSS17.0统计软件分析。结果:1.结肠镜肠黏膜改善情况,治疗组6例显效,14例有效,2例无效,总有效率90.91%;对照组4例显效,10例有效,8例无效,总有效率63.64%,治疗组优于对照组(P0.05)。2.两组患者治疗前后中医症候积分比较,治疗组改善优于对照组,差异有统计学意义(P0.05)。中医证候疗效情况比较,治疗组6例临床痊愈,8例显效,7例有效,1例无效,总有效率95.24%;对照组4例临床痊愈,5例显效,5例有效,8例无效,总有效率63.64%,总有效率相比治疗组优于对照组(P0.05)。3.两组疗程结束后,血清C反应蛋白比较治疗组下降幅度大于对照组,差异有统计学意义(P0.05)。结论:依据“肠痈”学术思想,自拟方药健脾助运汤以健脾祛湿,调理气血为治则,对脾虚湿蕴型溃疡性结肠炎进行中西医结合的治疗方案,能够显著改善患者临床症状,促进病变部位肠黏膜恢复,减轻患者痛苦,提高患者的生存质量。
[Abstract]:Objective: to take invigorating spleen and removing dampness and regulating qi and blood as the principle of treatment, to give the UC patients with spleen deficiency and dampness accumulation type self-prescription Jianpi Zhuyun decoction, combined with mesalazine sustained release granule oral administration. To observe the clinical treatment effect of spleen deficiency dampness accumulation type ulcerative colitis, and to compare the changes of intestinal mucosa, clinical symptoms and signs and C-reactive protein before and after treatment. Methods: 44 patients with ulcerative colitis were selected. All the patients from January 2014 to December 2015 in the Department of spleen and stomach of affiliated Hospital of Liaoning University of traditional Chinese Medicine. The patients were randomly divided into two groups: treatment group and control group. 22 patients in each group were treated with the same basic treatment, while the control group was treated with mesalazine sustained release granules (1.0 g, 3 times a day). On the basis of the control group, the treatment group was given 100 ml of Jianpi decoction, three times a day, the course of treatment was 8 weeks. The clinical symptoms of the two groups before and after treatment were scored. The changes of mucosal healing and C-reactive protein in colonoscopy were compared. The data were analyzed by SPSS17.0 software. Results: 1. The improvement of intestinal mucosa in colonoscopy was effective in 14 cases in the treatment group (6 cases). 2 cases were ineffective, the total effective rate was 90.91%; The control group (n = 4) was effective in 10 cases (n = 8) and the total effective rate was 63.64 (n = 8). The treatment group was superior to the control group (P 0.05) .2.The scores of TCM symptoms before and after treatment were compared between the two groups. The improvement in the treatment group was better than that in the control group, and the difference was statistically significant (P 0.05). The curative effect of TCM syndrome in the treatment group was compared. In the treatment group, there were 6 cases of clinical recovery and 8 cases of remarkable effect, 7 cases were effective and 1 case was ineffective. The total effective rate was 95.2445; In the control group, 4 cases were clinically cured, 5 cases were markedly effective, 8 cases were ineffective, the total effective rate was 63.64, the total effective rate was better than that of the control group (P 0.05). 3. After the two treatment courses were finished, the total effective rate of the treatment group was better than that of the control group (P < 0.05). The decrease of serum C-reactive protein in the treatment group was greater than that in the control group, and the difference was statistically significant (P 0.05). Conclusion: according to the academic thought of "intestinal carbuncle", the prescription of Jianpi Juyun decoction was formulated to invigorate the spleen and remove dampness. Regulating qi and blood for the treatment of spleen deficiency and dampness accumulation of ulcerative colitis combined with traditional Chinese and western medicine can significantly improve the clinical symptoms of patients, promote the recovery of intestinal mucosa in the lesion, and alleviate the pain of the patients. Improve the quality of life of patients.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
，

本文编号：1361633