加味都气丸治疗慢性阻塞性肺疾病稳定期肺肾两虚证的临床研究

发布时间：2017-12-31 23:27

本文关键词：加味都气丸治疗慢性阻塞性肺疾病稳定期肺肾两虚证的临床研究　出处：《福建中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察评估加味都气丸对慢性阻塞性肺疾病稳定期肺肾两虚证患者的症状积分、BODE指数、慢阻肺评估问卷(CAT)评分的影响,以初步探究加味都气丸治疗慢性阻塞性肺疾病稳定期的临床疗效。方法：本试验选择符合纳入标准的慢性阻塞性肺疾病稳定期肺肾两虚证患者60例,采用随机对照的设计方案分为对照组30例,治疗组30例。对照组应用吸入噻托溴铵粉雾剂(18ug/吸),治疗组在对照组的基础上加服加味都气丸,疗程均为3个月。疗程结束后比较治疗前后临床症状积分,体重指数(BMI)、第1秒用力呼气容积占预计值百分比(FEV1%)、呼吸困难分级(mMRC)、6分钟步行距离(6MWD)、BODE,总积分及慢性阻塞性肺疾病评估测试(CAT)评分的变化。资料收集和整理后采用SPSS 18.0统计软件进行统计学分析。结果：1、两组症状积分及疗效比较：治疗后两组各个单项症状改善均有统计学差异(P0.05)。治疗组与对照组治疗后积分比较,除咳嗽、咳痰、喘息、易感冒外,其余指标差异有统计学意义(P0.05)。治疗组总有效率为96.42%,对照组总有效率为75%,两组总有效率差异有统计学意义。结果表明治疗组治疗效果优于对照组,尤其在改善乏力、畏寒、腰膝酸软方面治疗组优于对照组。2、两组BODE指数比较：治疗组治疗后体重指数、呼吸困难指数、6分钟步行距离、BODE,总积分较治疗前差异有统计学意义(P0.05)。对照组呼吸困难指数、6分钟步行距离、BODE,总积分较治疗前有统计学意义(P0.05),其余各项差异无统计学意义。两组治疗后比较,除治疗组呼吸困难指数、6分钟步行距离、BODE总积分较对照组差异有统计学意义(P0.05),其余指标均无统计学意义。结果表明两组治疗均可以改善患者的呼吸困难程度、6分钟步行距离、降低BODE指数,且治疗组的改善程度优于对照组。3、CAT评分比较：两组治疗后分值均较治疗前有显著性差异(P0.05)。两组治疗后分值比较差异亦有统计学意义(P0.05)。表明经过两组治疗均可改善患者的生活质量,其中治疗组的改善程度优于对照组。结论：加味都气丸联合西医常规方案治疗慢性阻塞性肺疾病稳定期肺肾两虚证的患者与单纯西药组相比,可以明显改善患者临床症状,特别是对乏力、畏寒、腰膝酸软等肺外表现的改善,能明显提高患者的生活质量。
[Abstract]:Objective: To evaluate the modified gas symptom Pill on chronic obstructive pulmonary disease of lung and kidney deficiency syndrome in patients with two points, BODE index, COPD Assessment Questionnaire (CAT) score, clinical curative effect to explore modified gas pill in the treatment of stable chronic obstructive pulmonary disease. Methods: the test select 60 cases of patients with stable chronic obstructive pulmonary disease of lung and kidney deficiency syndrome were incorporated into the standard two, the design scheme of randomly divided into the control group of 30 cases, 30 cases in the treatment group. The control group used Tiotropium Bromide Powder for Inhalation (18ug/ absorption), inhalation treatment group in the control group based on the given modified Duqi pill, treatment for 3 months. After the end of treatment before and after the treatment, clinical symptoms, body mass index (BMI), FEV1 percentage of predicted value (FEV1%), dyspnea grade (mMRC), 6 minutes walking distance (6MWD), BODE, total score and chronic Obstructive pulmonary disease assessment test (CAT) score changes. After collecting and sorting data using SPSS 18 statistical software for statistical analysis. Results: 1, compared with two groups of symptoms and curative effect: there were statistically significant differences between the two groups to improve individual symptoms after treatment (P0.05). Compared with the treatment group and the control group scores after treatment in addition to cough, phlegm, wheezing, colds, other indexes were statistically significant difference (P0.05). The total effective rate of treatment group was 96.42%, control group total effective rate was 75%, the total efficiency of two groups had significant difference. The Meiji therapy effect in treatment group than the control group, especially in the improvement of fatigue, chills the control group,.2 treatment group than Yaoxisuanruan, BODE index of two groups: the treatment group after treatment, body mass index, dyspnea index, 6 minutes walking distance, BODE, the total scores were statistically significant (P0.05) control. Group of dyspnea index, 6 minutes walking distance, BODE, the total scores were statistically significant (P0.05), no statistically significant difference. The rest of the two groups after treatment in treatment group, dyspnea index, 6 minutes walking distance, BODE total score than the control group the difference was statistically significant (P0.05), were no statistical significance of other indexes. The results show that the two groups can improve the patient's respiratory difficulty, 6 minutes walking distance, reduce the BODE index, and the treatment group improved more in the control group.3, CAT score comparison: two groups after treatment the scores were compared with before treatment, there was significant difference in two groups (P0.05). After the score there were significant differences (P0.05). After that the two groups can improve the quality of life of patients, the treatment group improved more in control group. Conclusion: modified Duqi pill combined with conventional western medicine treatment of chronic Compared with obstructive pulmonary disease stable stage two deficiency of lung and kidney of patients with pure western medicine group, can significantly improve the clinical symptoms, especially for fatigue, chills, Yaoxisuanruan extrapulmonary manifestations improved, can significantly improve the quality of life of patients.

【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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